Background & Aims Bile acid nuclear receptor farnesoid X receptor (FXR) is a key molecular
mediator of many metabolic processes, including the regulation of bile acid, lipid and …

Fibroblast growth factor 19 (FGF19) is a gut-derived peptide hormone that is produced
following activation of Farnesoid X Receptor (FXR). FGF19 is secreted and signals to the …

Hepatic accumulation of bile acids is central to the pathogenesis of cholestatic liver
diseases. Endocrine hormone fibroblast growth factor 19 (FGF19) may reduce hepatic bile …

Critical regulation of bile acid (BA) pool size and composition occurs via an intensive
molecular crosstalk between the liver and gut, orchestrated by the combined actions of the …

Fibroblast growth factor 19 (FGF19) is a hormone-like protein that regulates carbohydrate,
lipid and bile acid metabolism. At supra-physiological doses, FGF19 also increases …

Fibroblast growth factor 21 (FGF21) is a potent regulator of glucose and lipid homeostasis in
vivo; its most closely related subfamily member, FGF19, is known to be a critical negative …

Introduction: Fibroblast growth factor 19 (FGF19) is a member of the hormone-like FGF
family and has activity as an ileum-derived postprandial hormone. It shares high binding …

Hepatic bile acid synthesis is subject to complex modes of transcriptional control, in which
the bile acid-activated nuclear receptor farnesoid X receptor (FXR) in liver and intestine …

Elevated bile acid (BA) concentrations in the liver is associated with severe disease,
including cholestasis and hepatocellular carcinoma. The nuclear Farnesoid X Receptor …

Inappropriate fibroblast growth factor (FGF) signaling is involved in most tissue‐specific
pathologies including cancer. Previously we showed that inappropriate expression and …