Inflammatory diseases decrease the extracellular environmental pH. However, whether
proton-activated G protein-coupled receptors (GPCRs) can regulate the development of …

Acidic tissue microenvironment commonly exists in inflammatory diseases, tumors, ischemic
organs, sickle cell disease, and many other pathological conditions due to hypoxia …

It is well known that free fatty acids (FFAs) have beneficial effects on the skeletal system,
however, which fatty acid sensing GPCR (s) and how the GPCR (s) regulating cartilage …

Owing to the rapid aging of society, the numbers of patients with joint disease continue to
increase. Accordingly, a large number of patients require appropriate treatment for …

Spondyloarthritis encompasses a group of common inflammatory diseases thought to be
driven by IL-17A-secreting type-17 lymphocytes. Here we show increased numbers of GM …

Osteoporosis-related bone fracture and falls have a severe impact on patients' daily lives.
Osteoblasts are bone-building cells that play a vital role in bone formation and remodeling …

The fate of infiltrating neutrophils in inflamed joints determines the development of acute
gouty arthritis (AGA). GPR105 highly expressed in human neutrophils is sensitive to …

GPR4 is a pH-sensing G protein-coupled receptor highly expressed in vascular endothelial
cells and can be activated by protons in the inflamed tissue microenvironment. Herein, we …

Background Colorectal cancer (CRC) is one of the high incidences tumours and is ranked
second in cancer-related mortality. Even though great progress has been made, there are …

Background and aims Atherosclerosis is driven by an inflammatory process of the vascular
wall. The novel orphan G-protein coupled receptor 5B of family C (GPRC5B) is involved in …