Small molecules as cancer targeting ligands: Shifting the paradigm

N Kaur, P Popli, N Tiwary, R Swami - Journal of Controlled Release, 2023 - Elsevier
Conventional chemotherapeutics exploration is hampered due to their nonspecific
distribution leading to unintended serious toxicity. Toxicity is so severe that deciding to go for …

Small molecules for active targeting in cancer

CS Kue, A Kamkaew, K Burgess… - Medicinal research …, 2016 - Wiley Online Library
For the purpose of this review, active targeting in cancer research encompasses strategies
wherein a ligand for a cell surface receptor expressed on tumor cells is used to deliver a …

Engineering small molecule nanodrugs to overcome barriers for cancer therapy

Y Ma, Q Mou, D Yan, X Zhu - View, 2020 - Wiley Online Library
Small molecule nanodrugs consisting of pure drugs, drug‐drug dimers, drug‐drug
conjugates, or drug derivatives could realize drug delivery by themselves without the aid of …

Role of small molecule targeted compounds in cancer: progress, opportunities, and challenges

G Sun, D Rong, Z Li, G Sun, F Wu, X Li… - Frontiers in cell and …, 2021 - frontiersin.org
Research on molecular targeted therapy of tumors is booming, and novel targeted therapy
drugs are constantly emerging. Small molecule targeted compounds, novel targeted therapy …

Small molecule drug conjugates (SMDCs): an emerging strategy for anticancer drug design and discovery

TK Patel, N Adhikari, SA Amin, S Biswas… - New Journal of …, 2021 - pubs.rsc.org
Traditional chemotherapy mostly relies on the use of cytotoxic agents, which are typically
unable to preferentially localize at the tumor microenvironment resulting in off-target toxicity …

Stimulus-responsive macromolecules and nanoparticles for cancer drug delivery

SR MacEwan, DJ Callahan, A Chilkoti - Nanomedicine, 2010 - Taylor & Francis
Nanoparticles and macromolecular carriers have been widely used to increase the efficacy
of chemotherapeutics, largely through passive accumulation provided by the enhanced …

Recent progress of supramolecular chemotherapy based on host–guest interactions

M Yan, S Wu, Y Wang, M Liang, M Wang… - Advanced …, 2024 - Wiley Online Library
Chemotherapy is widely recognized as an effective approach for treating cancer due to its
ability to eliminate cancer cells using chemotherapeutic drugs. However, traditional …

Recent advances in biocompatible nanocarriers for delivery of chemotherapeutic cargoes towards cancer therapy

CY Ang, SY Tan, Y Zhao - Organic & biomolecular chemistry, 2014 - pubs.rsc.org
Cancer is currently one of the major diseases that has gained a lot of scientific attention.
Conventional cancer therapeutics involve surgical removal of tumors from patients followed …

Robust and smart polypeptide-based nanomedicines for targeted tumor therapy

C Deng, Q Zhang, J Guo, X Zhao, Z Zhong - Advanced drug delivery …, 2020 - Elsevier
Nanomedicines based on synthetic polypeptides are among the most versatile and
advanced platforms for tumor therapy. Notably, several polypeptide-based nanodrugs are …

[HTML][HTML] Peptide-decorated polymeric nanomedicines for precision cancer therapy

H Sun, Y Dong, J Feijen, Z Zhong - Journal of controlled release, 2018 - Elsevier
The advancement of tissue and cell-specific drug delivery systems is a key to precision
cancer therapy. Peptides, with easy synthesis, low immunogenicity and biological functions …