The function of p53 is best understood in response to genotoxic stress, but increasing
evidence suggests that p53 also plays a key role in the regulation of metabolic homeostasis …

Abstract p53 is an important tumour suppressor gene, with loss of p53 contributing to the
development of most human cancers. However, the activation of p53 in response to stress …

Simple Summary The p53 pathway is a major tumor suppressor pathway that prevents the
propagation of abnormal cells by regulating DNA repair, cell cycle progression, cell death, or …

Background The TP53 gene is one of the most commonly inactivated tumor suppressors in
human cancers. p53 functions during cancer progression have been linked to a variety of …

We are increasingly aware that cellular metabolism plays a vital role in diseases such as
cancer, and that p53 is an important regulator of metabolic pathways. By transcriptional …

During the course of tumorigenesis, cells acquire a number of alterations that contribute to
the acquisition of the malignant phenotype, allowing them to survive and flourish in …

The function of p53 as a tumour suppressor has been attributed to its ability to promote cell
death or permanently inhibit cell proliferation. However, in recent years, it has become clear …

Tumor-suppressor p53 plays a key role in tumor prevention. As a transcription factor, p53
transcriptionally regulates its target genes to initiate different biological processes in …

The p53 family of transcription factors is essential to counteract tumour formation and
progression. Although previously this was exclusively associated with the ability of the p53 …

Abstract p53 plays a key role in tumor suppression. The tumor suppressive function of p53
has long been attributed to its ability to induce apoptosis, cell cycle arrest, and senescence …