Atherosclerosis is primarily a disorder of lipid metabolism, but there is also a prominent
chronic inflammatory component that drives the atherosclerotic lesion progression in the …

The potential role of anti-inflammatory cytokines in the modulation of the atherosclerotic
process remains unknown. Interleukin (IL)-10 has potent deactivating properties in …

Understanding of the pathophysiology of atherosclerosis has changed markedly over the
past few decades. It is now widely accepted that inflammation plays a fundamental role in …

ABSTRACT Interleukin-6 (IL-6) is a unique pleiotropic cytokine exhibiting both pro-and anti-
inflammatory properties depending on the target cell type. Plasma IL-6 levels are associated …

It has recently been appreciated that atherosclerosis is predominantly an inflammatory
process. Atherosclerosis begins with a fatty streak, which is made up almost entirely of …

Atherosclerosis can be viewed in part as an inflammatory disease process and may
therefore be susceptible to manipulation of the immune state. Interleukin 10 (IL-10) is an …

The importance of inflammation as a driver of pathology is no longer confined to
autoimmune and infectious diseases. In line with convincing experimental data as well as …

Objective: Marked anti-atheromatous effects of the anti-inflammatory cytokine interleukin-10
(IL-10) were observed in several lipid-driven animal models of arteriosclerosis. We therefore …

In atherogenesis, macrophage foam cell formation is modulated by pathways involving both
the uptake and efflux of cholesterol. We recently showed that interleukin-10 (IL-10) …

Interleukin (IL)-10 may have a therapeutic potential in atherosclerosis, but its mechanisms of
action have not been clarified. Foam cell formation is a key event in atherogenesis, and …