Metabolic signature of energy metabolism alterations and excess nitric oxide production in culture media correlate with low human embryo quality and unsuccessful …

R Pallisco, G Lazzarino, G Bilotta, F Marroni… - International Journal of …, 2023 - mdpi.com
Notwithstanding the great improvement of ART, the overall rate of successful pregnancies
from implanted human embryos is definitely low. The current routine embryo quality …

Non-invasive human embryo metabolic assessment as a developmental criterion

M Motiei, K Vaculikova, A Cela, K Tvrdonova… - Journal of Clinical …, 2020 - mdpi.com
The selection of a highly-viable single embryo in assisted reproductive technology requires
an acceptable predictive method in order to reduce the multiple pregnancy rate and …

Applying metabolomic analyses to the practice of embryology: physiology, development and assisted reproductive technology

RL Krisher, AL Heuberger, M Paczkowski… - Reproduction …, 2015 - CSIRO Publishing
The advent of metabolomics technology and its application to small samples has allowed us
to non-invasively monitor the metabolic activity of embryos in a complex culture …

GC-MS/MS analysis of metabolites derived from a single human blastocyst

N Inoue, Y Nishida, E Harada, K Sakai, H Narahara - Metabolomics, 2021 - Springer
Introduction The field of assisted reproductive technology (ART) has significantly advanced;
however, morphological evaluation remains as the chosen method of assessment of embryo …

Solution NMR in human embryo culture media as an option for assessment of embryo implantation potential

AM Salmerón, AC Abreu, M Vilches‐Ferrón… - NMR in …, 2021 - Wiley Online Library
NMR offers the potential to holistically screen hundreds of metabolites and has already
proved to be a powerful technique able to provide a global picture of metabolic changes in a …

Metabolomics and its application for non-invasive embryo assessment in IVF

L Botros, D Sakkas, E Seli - Molecular human reproduction, 2008 - academic.oup.com
Morphology and cleavage rate remain the mainstay of embryo assessment. However, a
number of additional technologies for this application are under investigation. These include …

Metabolomics Integration in Assisted Reproductive Technologies for Enhanced Embryo Selection beyond Morphokinetic Analysis

S Pinto, B Guerra-Carvalho, L Crisóstomo… - International Journal of …, 2023 - mdpi.com
Embryo quality evaluation during in vitro development is a crucial factor for the success of
assisted reproductive technologies (ARTs). However, the subjectivity inherent in the …

[HTML][HTML] Noninvasive metabolomic profiling as an adjunct to morphology for noninvasive embryo assessment in women undergoing single embryo transfer

E Seli, CG Vergouw, H Morita, L Botros, P Roos… - Fertility and sterility, 2010 - Elsevier
OBJECTIVE: To determine whether metabolomic profiling of spent embryo culture media
correlates with reproductive potential of human embryos. DESIGN: Retrospective study …

NMR studies of preimplantation embryo metabolism in human assisted reproductive techniques: a new biomarker for assessment of embryo implantation potential

SM Pudakalakatti, S Uppangala, F D'Souza… - NMR in …, 2013 - Wiley Online Library
There has been growing interest in understanding energy metabolism in human embryos
generated using assisted reproductive techniques (ART) for improving the overall success …

[HTML][HTML] Analysis of metabolism to select viable human embryos for transfer

DK Gardner, PL Wale - Fertility and sterility, 2013 - Elsevier
As we move to reducing the number of embryos transferred in a given IVF cycle, ideally
down to one, there is an ever-increasing need for noninvasive quantitative markers of …