Recombinant human T-cell leukemia virus types 1 and 2 Tax proteins induce high levels of CC-chemokines and downregulate CCR5 in human peripheral blood …

CS Barrios, M Abuerreish, MD Lairmore… - Viral …, 2011 - liebertpub.com
Human T-cell leukemia viruses types 1 (HTLV-1) and 2 (HTLV-2) produce key transcriptional
regulatory gene products, known as Tax1 and Tax2, respectively. Tax1 and Tax2 …

Tax-inducible production of CC chemokine ligand 22 by human T cell leukemia virus type 1 (HTLV-1)-infected T cells promotes preferential transmission of HTLV-1 to …

K Hieshima, D Nagakubo, T Nakayama… - The Journal of …, 2008 - journals.aai.org
Adult T cell leukemia is a mature CD4+ T cell malignancy which predominantly expresses
CCR4 and is etiologically associated with human T cell leukemia virus type 1 (HTLV-1) …

Human T cell leukaemia virus type 2 tax protein mediates CC-chemokine expression in peripheral blood mononuclear cells via the nuclear factor kappa B canonical …

CS Barrios, L Castillo, H Zhi, CZ Giam… - Clinical & …, 2014 - academic.oup.com
Retroviral co-infections with human immunodeficiency virus type-1 (HIV-1) and human T cell
leukaemia virus type 1 (HTLV-1) or type 2 (HTLV-2) are prevalent in many areas worldwide …

Characterization of peripheral blood T-lymphocytes transduced with HTLV-I Tax mutants with different trans-activating phenotypes

T Akagi, H Ono, H Nyunoya, K Shimotohno - Oncogene, 1997 - nature.com
Tax1, a transcriptional trans-activator of the Human T-cell leukemia virus type I (HTLV-I),
induces the expression of many cellular genes through interaction with at least three distinct …

The transcription profile of Tax-3 is more similar to Tax-1 than Tax-2: insights into HTLV-3 potential leukemogenic properties

SA Chevalier, S Durand, A Dasgupta, M Radonovich… - PLoS …, 2012 - journals.plos.org
Human T-cell Lymphotropic Viruses type 1 (HTLV-1) is the etiological agent of Adult T-cell
Leukemia/Lymphoma. Although associated with lymphocytosis, HTLV-2 infection is not …

Human T cell leukemia virus type-I Tax activates human macrophage inflammatory protein-3α/CCL20 gene transcription via the NF-κB pathway

Y Imaizumi, S Sugita, K Yamamoto… - International …, 2002 - academic.oup.com
Infection by human T cell leukemia virus type (HTLV)-I is associated with several diseases,
including adult T cell leukemia and HTLV-I-associated myelopathy/tropical spastic …

Induction of CC-chemokines with antiviral function in macrophages by the human T lymphotropic virus type 2 transactivating protein, Tax2

G Balistrieri, CS Barrios, L Castillo… - Viral …, 2013 - liebertpub.com
Recent data provide evidence that co-infection with human immunodeficiency virus type 1
(HIV-1) and human T lymphotropic virus type 2 (HTLV-2) delays progression to AIDS …

Identification of a novel motif responsible for the distinctive transforming activity of human T-cell leukemia virus (HTLV) type 1 Tax1 protein from HTLV-2 Tax2

T Shoji, M Higuchi, R Kondo, M Takahashi, M Oie… - Retrovirology, 2009 - Springer
Background Human T-cell leukemia virus type 1 (HTLV-1) is a causative agent of adult T-cell
leukemia (ATL), whereas its relative HTLV-2 is not associated with any malignancies …

Human T-cell leukemia virus type-1 Tax oncoprotein regulates G-protein signaling

JC Twizere, JY Springael, M Boxus, A Burny… - Blood, 2007 - ashpublications.org
Human T-cell leukemia virus type-1 (HTLV-1), the first pathogenic retrovirus discovered in
humans 26 years ago, 1 is the causative agent of 2 major diseases: a rapidly fatal leukemia …

Human T-cell leukemia virus type 1 Tax protein induces the expression of STAT1 and STAT5 genes in T-cells

N Nakamura, M Fujii, T Tsukahara, M Arai, T Ohashi… - Oncogene, 1999 - nature.com
Human T-cell leukemia virus type 1 (HTLV-1) Tax transforms normal T-cells in the presence
of interleukin (IL)-2 in vitro. STAT is a family of transcription factors that play a pivotal role in …