Background The cumulus expansion process is one of the LH mediated ovulatory
processes. Hyaluronan synthase 2 (HAS2) regulates the synthesis of hyaluronic acid, the …

In adult ovary, WNT5A is involved in follicular responses to gonadotropins and necessary for
ovarian follicle development. However, the mechanism by which gonadotropins regulate …

Hyaluronan serves as a structural component of ovarian follicles, and hyaluronan-mediated
signaling cascades lead to follicular development, oocyte maturation, and ovulation …

Background With advanced maternal age, abnormalities during oocyte meiosis increase
significantly. Aneuploidy is an important reason for the reduction in the quality of aged …

In response to the gonadotropin surge, the compact cumulus-oocyte complex (COC)
undergoes expansion by synthesis of the mucopolysaccharide hyaluronan (HA) …

In contrast to other species, the preovulatory rise in gonadotropins in mares causes a
remarkable expansion of the entire granulosa cell layer in vivo, suggesting that hyaluronan …

Abstract Objective (s) CHL1 (close homologue of L1 or cell adhesion molecule L1 like), also
referred as CALL, is a member of the L1 gene family of neural cell adhesion molecules and …

Integrin β3 (ITGB3), which is the target gene of the miRNA let-7 that can be antagonized by
long noncoding RNA (lncRNA) H19, is well-known to have a critical role in endometrium …

Although the role of the Hippo signaling pathway in development and tumorigenesis has
been extensively studied in multiple organs, its role in ovarian follicle development remains …

RNA interference (RNAi) is an effective tool for studying gene function in oocytes, but no
studies have targeted somatic cells of primary cultured cumulus cell–oocyte complexes …