Spray dried powders for nasal delivery: Process and formulation considerations

P Henriques, A Fortuna, S Doktorovová - European Journal of …, 2022 - Elsevier
Powders for nasal delivery have been recognized as advantageous dosage forms over
liquids due to increased stability and residence time on nasal mucosa, with improved …

Engineered nasal dry powder for the encapsulation of bioactive compounds

A Baldelli, MA Boraey, H Oguzlu, A Cidem… - Drug Discovery …, 2022 - Elsevier
Highlights•Particle engineering can be used to design stable dry powder to be nasally
delivered;•Spray and spray freeze drying show the highest control over the properties of dry …

Opportunity and challenges of nasal powders: Drug formulation and delivery

LT Fasiolo, MD Manniello, E Tratta, F Buttini… - European Journal of …, 2018 - Elsevier
In the field of nasal drug delivery, among the preparations defined by the European
Pharmacopoeia, nasal powders facilitate the formulation of poorly water-soluble active …

[HTML][HTML] Nasal powder formulations: In-vitro characterisation of the impact of powders on nasal residence time and sensory effects

M Trenkel, R Scherließ - Pharmaceutics, 2021 - mdpi.com
Nasal drug delivery is still primarily associated with locally-effective drugs, but next-
generation products utilising the benefits of nasal administration—such as easy access to a …

Impact of amino acids on the properties of nasal dry powders

A Baldelli, C Wong, H Oguzlu, H Mahvizani… - Journal of Drug Delivery …, 2023 - Elsevier
Spray freeze drying is an appropriate technique for producing nasally delivered inhalable
encapsulated drugs since producing microparticles with a diameter larger than 100 μm …

Dry powder nasal drug delivery: challenges, opportunities and a study of the commercial Teijin Puvlizer Rhinocort device and formulation

M Pozzoli, P Rogueda, B Zhu, T Smith… - Drug development …, 2016 - Taylor & Francis
Purpose: To discuss the challenges and opportunities for dry powder nasal medications and
to put this in to perspective by evaluating and characterizing the performance of the Teijin …

Optimising nasal powder drug delivery–characterisation of the effect of excipients on drug absorption

M Trenkel, R Scherließ - International journal of pharmaceutics, 2023 - Elsevier
The nasal physiology offers great potential for drug delivery but also poses specific
challenges, among which the short residence time of applied drugs is one of the most …

Caffeine microparticles for nasal administration obtained by spray drying

C Sacchetti, M Artusi, P Santi, P Colombo - International journal of …, 2002 - Elsevier
This study investigated the possibility to use spray drying technique to prepare powders
formulations containing caffeine intended for nasal delivery. Spray dried powders containing …

[HTML][HTML] Designing enhanced spray dried particles for inhalation: A review of the impact of excipients and processing parameters on particle properties

N Alhajj, NJ O'Reilly, H Cathcart - Powder Technology, 2021 - Elsevier
Spray drying is a constructive single-step manufacturing technique used to produce dry
powder. Spray drying plays a remarkable role in producing inhalable powder formulations …

Preliminary study of nanonized lamotrigine containing products for nasal powder formulation

P Gieszinger, I Csóka, E Pallagi, G Katona… - Drug Design …, 2017 - Taylor & Francis
The nasal delivery of drugs offers a great alternative route to avoid adverse events and to
increase patient compliance due to its advantageous properties. Besides nasal application …