The coevolution of mammalian hosts and their beneficial commensal microbes has led to
development of symbiotic host–microbiota relationships. Epigenetic machinery permits …

The development and severity of inflammatory bowel diseases and other chronic
inflammatory conditions can be influenced by host genetic and environmental factors …

Background & Aims Intestinal microbiota modulate metabolism and associate closely with
epithelial cells in the intestine. In intestinal epithelial cells (IECs), histone deacetylase 3 …

The human intestine, colonized by a dense community of resident microbes, is a frequent
target of bacterial pathogens. Undisturbed, this intestinal microbiota provides protection from …

Aberrant immune responses to resident microbes promote inflammatory bowel disease and
other chronic inflammatory conditions. However, how microbiota-specific immunity is …

Circadian rhythmicity is a defining feature of mammalian metabolism that synchronizes
metabolic processes to day-night light cycles. Here, we show that the intestinal microbiota …

Cooperative phenotypes are considered central to the functioning of microbial communities
in many contexts, including communication via quorum sensing, biofilm formation, antibiotic …

Long-term dietary intake influences the structure and activity of the trillions of
microorganisms residing in the human gut,,,,, but it remains unclear how rapidly and …

The microbiome has an important role in human health. Changes in the microbiota can
confer resistance to or promote infection by pathogenic bacteria. Antibiotics have a profound …

Histone-modifying enzymes regulate transcription and are sensitive to availability of
endogenous small-molecule metabolites, allowing chromatin to respond to changes in …