Context: Babies of obese women are often large at birth, which is associated with perinatal
complications and metabolic syndrome later in life. The mechanisms linking maternal …

Fetal overgrowth is common in obese women and is associated with perinatal complications
and increased risk for the child to develop metabolic syndrome later in life. Placental nutrient …

Objective To identify possible mechanisms linking obesity in pregnancy to increased fetal
adiposity and growth, a unique mouse model of maternal obesity associated with fetal …

Maternal obesity is associated with pregnancy complications and increases the risk for the
infant to develop obesity, diabetes and cardiovascular disease later in life. However, the …

The mechanisms by which maternal nutrient restriction (MNR) causes reduced fetal growth
are poorly understood. We hypothesized that MNR inhibits placental mechanistic target of …

The mTOR (mammalian target of rapamycin) signalling pathway functions as a nutrient
sensor, both in individual cells and, more globally, in organs such as the fat body in …

Key points Inadequate nutrient supply during fetal life results in intrauterine growth
restriction (IUGR), which may lead to obesity, diabetes, and cardiovascular disease later in …

Placental amino acid transport is decreased in intrauterine growth restriction (IUGR);
however, the underlying mechanisms remain largely unknown. We have shown that …

Intrauterine growth restriction (IUGR) represents an important risk factor for perinatal
complications and for adult disease. IUGR is associated with a down‐regulation of placental …

HYPOTHESIS AND STUDY OBJECTIVES: We hypothesized that maternal obesity is
associated with increased placental amino acid transport and hyperleptinemia. Our …