Wnt and PPARγ signaling in osteoblastogenesis and adipogenesis
I Takada, AP Kouzmenko, S Kato - Nature Reviews Rheumatology, 2009 - nature.com
Osteoblasts and adipocytes differentiate from a common pluripotent precursor, the
mesenchymal stem cell (MSC). Studies have identified numerous transcription factors, and …
mesenchymal stem cell (MSC). Studies have identified numerous transcription factors, and …
PPARγ and Wnt signaling in adipogenic and osteogenic differentiation of mesenchymal stem cells
Z Yuan, Q Li, S Luo, Z Liu, D Luo… - Current stem cell …, 2016 - ingentaconnect.com
Mesenchymal stem cells (MSCs) arise from a variety of tissues, including bone marrow and
adipose tissue and, accordingly, have the potential to differentiate into multiple cell types …
adipose tissue and, accordingly, have the potential to differentiate into multiple cell types …
Molecular switching of osteoblastogenesis versus adipogenesis: implications for targeted therapies
I Takada, AP Kouzmenko, S Kato - Expert opinion on therapeutic …, 2009 - Taylor & Francis
Osteoblasts and adipocytes differentiate from a common precursor, the pluripotent
mesenchymal stem cell (MSC) found in bone marrow (BMSC) and adipose tissue (AD …
mesenchymal stem cell (MSC) found in bone marrow (BMSC) and adipose tissue (AD …
PPAR-γ and Wnt regulate the differentiation of MSCs into adipocytes and osteoblasts respectively
Y Li, D Jin, W Xie, L Wen, W Chen, J Xu… - Current stem cell …, 2018 - ingentaconnect.com
Background: Under the transcriptional control of numerous factors and intracellular signals,
mesenchymal stem cells (MSCs) can differentiate into various cell types, including …
mesenchymal stem cells (MSCs) can differentiate into various cell types, including …
Cross-talking between PPAR and WNT signaling and its regulation in mesenchymal stem cell differentiation
C Xu, J Wang, T Zhu, Y Shen, X Tang… - Current stem cell …, 2016 - ingentaconnect.com
The pluripotent mesenchymal stem cells (MSC) are common precursors to adipocytes and
osteoblasts. Large numbers of extracellular and intracellular signals and transcription factors …
osteoblasts. Large numbers of extracellular and intracellular signals and transcription factors …
Wnt signaling stimulates osteoblastogenesis of mesenchymal precursors by suppressing CCAAT/enhancer-binding protein α and peroxisome proliferator-activated …
Mesenchymal precursor cells have the potential to differentiate into several cell types,
including adipocytes and osteoblasts. Activation of Wnt/β-catenin signaling shifts …
including adipocytes and osteoblasts. Activation of Wnt/β-catenin signaling shifts …
Suppression of PPAR transactivation switches cell fate of bone marrow stem cells from adipocytes into osteoblasts
I Takada, M Suzawa, K Matsumoto… - Annals of the New York …, 2007 - Wiley Online Library
Osteoblasts and adipocytes differentiate from common pleiotropic mesenchymal stem cells
under transcriptional controls by numerous factors and multiple intracellular signalings …
under transcriptional controls by numerous factors and multiple intracellular signalings …
Running against the Wnt: How Wnt/β-catenin suppresses adipogenesis
TJJ De Winter, R Nusse - Frontiers in cell and developmental biology, 2021 - frontiersin.org
Mesenchymal stem cells (MSCs) give rise to adipocytes, osteocytes, and chondrocytes and
reside in various tissues, including bone marrow and adipose tissue. The differentiation …
reside in various tissues, including bone marrow and adipose tissue. The differentiation …
Loss of wnt/β‐catenin signaling causes cell fate shift of preosteoblasts from osteoblasts to adipocytes
L Song, M Liu, N Ono, FR Bringhurst… - Journal of Bone and …, 2012 - academic.oup.com
Wnt signaling is essential for osteogenesis and also functions as an adipogenic switch, but it
is not known if interrupting wnt signaling via knockout of β‐catenin from osteoblasts would …
is not known if interrupting wnt signaling via knockout of β‐catenin from osteoblasts would …
Wnt6, Wnt10a and Wnt10b inhibit adipogenesis and stimulate osteoblastogenesis through a β-catenin-dependent mechanism
WP Cawthorn, AJ Bree, Y Yao, B Du, N Hemati… - Bone, 2012 - Elsevier
Wnt10b is an established regulator of mesenchymal stem cell (MSC) fate that inhibits
adipogenesis and stimulates osteoblastogenesis, thereby impacting bone mass in vivo …
adipogenesis and stimulates osteoblastogenesis, thereby impacting bone mass in vivo …