Amantadine and modafinil as neurostimulants following acute stroke: a retrospective study of intensive care unit patients

AM Leclerc, RR Riker, CS Brown, T May, K Nocella… - Neurocritical Care, 2021 - Springer
Abstract Background/Objective Neurostimulants may improve or accelerate cognitive and
functional recovery after intracerebral hemorrhage (ICH), ischemic stroke (IS), or …

Amantadine and modafinil as neurostimulants during post-stroke care: a systematic review

DJ Gagnon, AM Leclerc, RR Riker, CS Brown, T May… - Neurocritical care, 2020 - Springer
Amantadine and modafinil are neurostimulants that may improve cognitive and functional
recovery post-stroke, but the existing study results vary, and no comprehensive review has …

Comparison of amantadine, modafinil, and standard of care in the acute treatment of disorders of consciousness after severe traumatic brain injury

TD Hintze, CE Small, J Montgomery… - Clinical …, 2022 - journals.lww.com
Objective Traumatic brain injury (TBI) is a major cause of death and disability worldwide.
Many patients who experience severe TBI have persistent disorders of consciousness …

Amantadine treatment is associated with improved consciousness in patients with non-traumatic brain injury

L Rühl, JB Kuramatsu, JA Sembill… - Journal of Neurology …, 2022 - jnnp.bmj.com
Objective This study determined the effect of amantadine treatment on consciousness in
patients with non-traumatic brain injury. Methods We pooled individual patient data of five …

Amantadine for NeuroenhaNcement in acutE patients Study-a protocol for a prospective pilot proof of concept phase IIb study in intensive and intermediate care unit …

A Hofmann, C Blum, C Single, K Adeyemi, P Schwarz… - Bmc Neurology, 2023 - Springer
Background Persisting coma is a common complication in (neuro) intensive care in
neurological disease such as acute ischemic stroke, intracerebral hemorrhage or …

Stimulant therapy in acute traumatic brain injury: prescribing patterns and adverse event rates at 2 level 1 trauma centers

ME Barra, S Izzy, A Sarro-Schwartz… - Journal of intensive …, 2020 - journals.sagepub.com
Background/Objective: Pharmacological stimulant therapies are routinely administered to
promote recovery in patients with subacute and chronic disorders of consciousness (DoC) …

Placebo-controlled trial of amantadine for severe traumatic brain injury

JT Giacino, J Whyte, E Bagiella, K Kalmar… - … England Journal of …, 2012 - Mass Medical Soc
Background Amantadine hydrochloride is one of the most commonly prescribed medications
for patients with prolonged disorders of consciousness after traumatic brain injury …

Effect of amantadine on agitation in critically ill patients with traumatic brain injury

JA Gramish, BJ Kopp… - Clinical …, 2017 - journals.lww.com
Objective This study aimed to compare the presence of agitation in traumatic brain injury
patients treated with amantadine with those not treated with amantadine in the intensive …

The effects of amantadine on traumatic brain injury outcome: a double-blind, randomized, controlled, clinical trial

H Ghalaenovi, A Fattahi, J Koohpayehzadeh… - Brain injury, 2018 - Taylor & Francis
Introduction: Amantadine, as a dopamine receptor agonist, may stimulate and help the
recovery of the nervous system after traumatic brain injury (TBI). Methods: We performed this …

A review of pharmacologic neurostimulant use during rehabilitation and recovery after brain injury

S Kakehi, DM Tompkins - Annals of Pharmacotherapy, 2021 - journals.sagepub.com
Objective: To describe the efficacy and safety of pharmacologic neurostimulants after
neurological injuries such as ischemic or hemorrhagic stroke and traumatic brain injury …