Multiple sclerosis (MS) is a debilitating disease characterized by demyelination of the central
nervous system (CNS), resulting in widespread formation of white matter lesions (WMLs) …

Background and Objectives There is currently no consensus about the extent of gray matter
(GM) atrophy that can be attributed to secondary changes after white matter (WM) lesions or …

In multiple sclerosis (MS) it is emerging that the most visible element of pathology, white
matter (WM) lesions, represents only a fraction of the disease burden borne by the brain; …

Gray matter (GM) involvement is detected even in the earliest stages of multiple sclerosis
(MS), and GM atrophy occurs at a faster rate than white matter (WM) atrophy early in the …

The classical view of MS as a chronic inflammatory demyelinating disease leading to the
formation of focal central nervous system (CNS) white matter (WM) lesions has been …

Multiple sclerosis is characterized at the gross pathological level by the presence of
widespread focal demyelinating lesions of the myelin-rich white matter. However, it is …

Over the past decade, immunohistochemical studies have provided compelling evidence
that gray matter (GM) pathology in multiple sclerosis (MS) is extensive. Until recently, this …

Besides focal white matter lesions, multiple sclerosis brain tissue also displays
abnormalities in the gray matter and the normal-appearing white matter. Recent advances in …

The purpose of this special issue in BMC Neurology is to summarize advances in our
understanding of the pathological, immunological, imaging and clinical concepts of gray …

Ž. The traditional description of multiple sclerosis MS emphasizes the notion that this
disease is an inflammatoryrdemyelinating condition of the white matter of the Ž. central …