Chemical modifications of DNA and RNA regulate genome functions or trigger mutagenesis
resulting in aging or cancer. Oxidations of macromolecules, including DNA, are common …

The generation of reactive oxygen species may be both beneficial to cells, performing a
function in inter-and intracellular signalling, and detrimental, modifying cellular …

Living organisms are constantly exposed to oxidative stress from environmental agents and
from endogenous metabolic processes. The resulting oxidative modifications occur in …

Living organisms are constantly exposed to oxidative stress from environmental agents and
from endogenous metabolic processes. The resulting oxidative modifications occur in …

The integrity of the genetic information is continuously challenged by numerous genotoxic
insults, most frequently in the form of oxidation, alkylation or deamination of the bases that …

Redox homeostasis refers to the balance between the production of reactive oxygen species
(ROS) as well as reactive nitrogen species (RNS), and their elimination by antioxidants. It is …

Reactive oxygen and nitrogen species (eg H 2 O 2, nitric oxide) confer redox regulation of
essential cellular signaling pathways such as cell differentiation, proliferation, migration and …

Reactive oxygen and nitrogen species damage cellular macromolecules including DNA.
Cells have a robust base excision repair pathway to deal with this damage in both nuclear …

Oxidative stress and the resulting damage to genomic DNA are inevitable consequences of
endogenous physiological processes, and they are amplified by cellular responses to …

Oxidative damage to DNA appears to be a factor in cancer, yet explanations for why highly
elevated levels of such lesions do not always result in cancer remain elusive. Much of the …