Objective Alpha smooth muscle actin (alpha-SMA) expression in stroma is linked to the
presence of cancer-associated fibroblasts and is known to correlate with worse outcomes in …

In a single-cell RNA sequencing (scRNA-seq) study published in Cell, a team of researchers
have identified cancer cell phenotypes that can be used to classify tumour glands from …

Pancreatic ductal adenocarcinoma (PDAC) is highly heterogeneous and lethal. Long
noncoding RNAs (lncRNAs) are an important class of genes regulating tumorigenesis and …

Aims: Using Single-cell RNA sequencing (scRNA-seq), we explored the spatiotemporal
heterogeneity of pancreatic neuroendocrine tumors (pNETs) and the underlying mechanism …

Multiple endocrine neoplasia 1 (MEN1) syndrome, a disease arising from a genetic
predisposition to tumor development caused by MEN1 loss-of-function mutations, is …

During the course of pancreatic neuroendocrine tumors (NETs), they generally become
more heterogeneous with individual cells exhibiting distinct molecular fingerprints. This …

The tumor microenvironment (TME) presents a complex ecosystem comprising a diversity of
immune and stromal cell populations that influence tumor progression, drug delivery and …

To understand the architecture of a tissue it is necessary to know both the cell populations
and their physical relationships to one another. Single-cell RNA-Seq (scRNA-Seq) has …

Pancreatic cancer is characterized by an expansive, desmoplastic stroma that responds to
neoplastic signals from the malignant epithelium while also instigating a cacophony of …

Background/objectives An abundant stromal reaction is a hallmark of pancreatic ductal
adenocarcinoma (PDAC) and chronic pancreatitis (CP). The cells mainly responsible for the …