Spontaneous diabetes in B (io) B (reeding) rats is complex, polygenic, and recessively
inherited. Several crossing studies have demonstrated that beside the class II genes of the …

Diabetes in BB rats share many common features with human type 1 diabetes. One of them
is the complex and polygenic nature of disease. Analysis of cross hybrids of diabetic BB/OK …

Several crossing studies using diabetic BB/OK and diabetes-resistant rat strains have clearly
shown that the MHC class-II-genes of the RT1u haplotype (Iddm1) and the lymphopenia …

By several crossing studies it has been demonstrated that the MHC class-II genes of the
RT1uhaplotype, Iddm1, and the lymphopenia, Iddm2, are essential, but not sufficient for …

Diabetes-prone (DP) BB rats develop autoimmune type 1 diabetes spontaneously. At least
five loci are linked to disease expression: the major histocompatibility complex (iddm2), two …

Abstract The LEW. 1AR1-iddm/Ztm rat is a new animal model of type 1 diabetes mellitus,
which shows an autosomal recessive mode of inheritance for the diabetes-inducing gene …

The BB rat spontaneously develops insulin-dependent diabetes mellitus of autoimmune
etiology. From breeding studies, one of the genes necessary for the development of …

Abstract The LEW. 1AR1-iddm rat is an animal model of human type 1 diabetes mellitus
(T1DM) with an autosomal recessive mode of inheritance. T1DM susceptibility loci could be …

Diabetes in BB rats is genetically determined by at least two genes, the one gene mapping
to the MHC, the other residing in the genetic background. In order to be able to study the role …

BB rats develop type 1 diabetes and WOKW rats facets of the metabolic syndrome. Both
strains are common the RT1 u haplotype of major histocompatibility complex (MHC) which is …