Reinterpretation of the Wartburg effect leads to understanding aerobic glycolysis as a
process that provides considerable amount of molecular precursors for the production of …

The alteration of glucose metabolism is one of the first biochemical characteristics
associated with cancer cells since most of these cells increase glucose consumption and …

Cancer cells exhibit distinct energy metabolic pathways due to multiple oncogenic events. In
normoxia condition, the anaerobic glycolysis (Warburg effect) is highly observed in head …

Proliferating and tumour cells express the glycolytic isoenzyme, pyruvate kinase type M2
(M2-PK), which occurs in a highly active tetrameric form and in a dimeric form with low …

Metabolic reprogramming is considered one of the hallmarks in cancer and is characterized
by increased glycolysis and lactate production, even in the presence of oxygen, which leads …

More than 1 in 10 cases of cancer in the world are due to chronic viral infections. Viruses
induce oncogenesis by targeting the same pathways known to be responsible for neoplasia …

Post-translational modification (PTM) is an important step of signal transduction that
transfers chemical groups such as phosphate, acetyl and glycosyl groups from one protein …

Oncogenic types of human papillomaviruses (HPVs) are major human carcinogens. Cancer
cells typically exhibit metabolic alterations which support their malignant growth. These …

Cancer is the second most important cause of death and new therapy modalities continue to
be developed and evolved. Cancer cells' metabolism is far different from the normal, healthy …

Simple Summary Cancer represents unrestricted growth with the removal of conventional
brakes that control growth under normal conditions. This requires novel mechanisms to …