T cell exhaustion presents one of the major hurdles to cancer immunotherapy. Among
exhausted CD8+ tumor-infiltrating lymphocytes, the terminally exhausted subset contributes …

Immune oncology approaches of adoptive cell therapy and immune checkpoint blockade
aim to activate T cells to eliminate tumors. Normal stimulation of resting T cells induces …

Cancer and chronic infections induce T cell exhaustion, a hypofunctional fate carrying
distinct epigenetic, transcriptomic and metabolic characteristics. However, drivers of …

To date, no immunotherapy approaches have managed to fully overcome T-cell exhaustion,
which remains a mandatory fate for chronically activated effector cells and a major …

T cells have a pivotal protective role in defense against infection and cancer but also are
instrumental in the development of many autoimmune diseases. The regulation of nutrient …

Currently, a marked number of clinical trials on cancer treatment have revealed the success
of immunomodulatory therapies based on immune checkpoint inhibitors that activate tumor …

The majority of tumor-infiltrating T cells exhibit a terminally exhausted phenotype, marked by
a loss of self-renewal capacity. How repetitive antigenic stimulation impairs T cell self …

Highlights•Memory T cells have quiescent metabolism.•Activation of T cells triggers both
glycolysis and oxidative phosphorylation.•Elevated T cell metabolic activity is necessary at …

Tumor-specific CD8+ T cells are exposed to persistent antigenic stimulation which induces a
dysfunctional state called “exhaustion.” Though functioning to limit damage caused by …

Immunotherapy has revolutionized the treatment of cancer in recent years and achieved
overall success and long‐term clinical benefit in patients with a wide variety of cancer types …