Metabolic reprogramming of terminally exhausted CD8+ T cells by IL-10 enhances anti-tumor immunity
T cell exhaustion presents one of the major hurdles to cancer immunotherapy. Among
exhausted CD8+ tumor-infiltrating lymphocytes, the terminally exhausted subset contributes …
exhausted CD8+ tumor-infiltrating lymphocytes, the terminally exhausted subset contributes …
The complex integration of T-cell metabolism and immunotherapy
MZ Madden, JC Rathmell - Cancer Discovery, 2021 - AACR
Immune oncology approaches of adoptive cell therapy and immune checkpoint blockade
aim to activate T cells to eliminate tumors. Normal stimulation of resting T cells induces …
aim to activate T cells to eliminate tumors. Normal stimulation of resting T cells induces …
Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion
NE Scharping, DB Rivadeneira, AV Menk… - Nature …, 2021 - nature.com
Cancer and chronic infections induce T cell exhaustion, a hypofunctional fate carrying
distinct epigenetic, transcriptomic and metabolic characteristics. However, drivers of …
distinct epigenetic, transcriptomic and metabolic characteristics. However, drivers of …
Orthogonal cytokine engineering enables novel synthetic effector states escaping canonical exhaustion in tumor-rejecting CD8+ T cells
J Corria-Osorio, SJ Carmona, E Stefanidis… - Nature …, 2023 - nature.com
To date, no immunotherapy approaches have managed to fully overcome T-cell exhaustion,
which remains a mandatory fate for chronically activated effector cells and a major …
which remains a mandatory fate for chronically activated effector cells and a major …
Emerging concepts of T cell metabolism as a target of immunotherapy
CH Chang, EL Pearce - Nature immunology, 2016 - nature.com
T cells have a pivotal protective role in defense against infection and cancer but also are
instrumental in the development of many autoimmune diseases. The regulation of nutrient …
instrumental in the development of many autoimmune diseases. The regulation of nutrient …
Targeting tumor metabolism: a new challenge to improve immunotherapy
S Kouidhi, F Ben Ayed… - Frontiers in …, 2018 - frontiersin.org
Currently, a marked number of clinical trials on cancer treatment have revealed the success
of immunomodulatory therapies based on immune checkpoint inhibitors that activate tumor …
of immunomodulatory therapies based on immune checkpoint inhibitors that activate tumor …
Impaired mitochondrial oxidative phosphorylation limits the self-renewal of T cells exposed to persistent antigen
The majority of tumor-infiltrating T cells exhibit a terminally exhausted phenotype, marked by
a loss of self-renewal capacity. How repetitive antigenic stimulation impairs T cell self …
a loss of self-renewal capacity. How repetitive antigenic stimulation impairs T cell self …
[HTML][HTML] Metabolic reprograming of anti-tumor immunity
M Sukumar, RJ Kishton, NP Restifo - Current opinion in immunology, 2017 - Elsevier
Highlights•Memory T cells have quiescent metabolism.•Activation of T cells triggers both
glycolysis and oxidative phosphorylation.•Elevated T cell metabolic activity is necessary at …
glycolysis and oxidative phosphorylation.•Elevated T cell metabolic activity is necessary at …
Exhausted CD8+ T cells in the tumor immune microenvironment: new pathways to therapy
W Jiang, Y He, W He, G Wu, X Zhou, Q Sheng… - Frontiers in …, 2021 - frontiersin.org
Tumor-specific CD8+ T cells are exposed to persistent antigenic stimulation which induces a
dysfunctional state called “exhaustion.” Though functioning to limit damage caused by …
dysfunctional state called “exhaustion.” Though functioning to limit damage caused by …
Reinvigorating exhausted CD8+ cytotoxic T lymphocytes in the tumor microenvironment and current strategies in cancer immunotherapy
MA Hossain, G Liu, B Dai, Y Si, Q Yang… - Medicinal Research …, 2021 - Wiley Online Library
Immunotherapy has revolutionized the treatment of cancer in recent years and achieved
overall success and long‐term clinical benefit in patients with a wide variety of cancer types …
overall success and long‐term clinical benefit in patients with a wide variety of cancer types …