Background Morbidity and mortality remain high for ischemic stroke victims, and at present
these patients lack effective neuroprotective agents, which improve the cure rate. In recent …

Background Ischemic stroke is a serious cardiovascular disease with high morbidity and
mortality rates that affects millions of people worldwide. Currently, the only therapy with …

The present study aimed to investigate the neuroprotective effect of lycopene in a mouse
model of bilateral common carotid artery occlusion (BCCAO) and the role of the Nrf2/HO‑1 …

Oxidative stress is well known to play a pivotal role in cerebral ischemia–reperfusion injury.
On the basis of this fact, antioxidative agents have been demonstrated to be neuroprotective …

Oxidative stress is considered a major contributing factor in cerebral ischemia/reperfusion
injury. Phloretin, a dihydrochalcone belonging to the flavonoid family, is particularly rich in …

This study aimed to identify the effect of β-caryophyllene (BCP) pretreatment and elucidate
the Nrf2/HO-1 signaling mechanism after focal cerebral ischemia-reperfusion (IR) injury in …

Eupatorium perfoliatum L.(E. perfoliatium) has been used traditionally for treating fever,
malaria and inflammation‑associated diseases. Eupafolin, the extract of E. perfoliatium, was …

Background Microglia, neuron, and vascular cells constitute a dynamic functional
neurovascular unit, which exerts the crucial role in functional recovery after ischemic stroke …

Abstract Xueshuantong injection (Lyophilized, XST), extracted from the traditional Chinese
medicinal herb Panax notoginseng, has neuroprotective effect on cerebral ischemia …

The aim of our study was to investigate the protective effects and underlying mechanisms of
myricetin, a bioactive food compound, on brain injury and neurological deficits after ischemic …