In the 1980s, epidemiological and molecular data suggested that cancers arising at different
subsites may be biologically disparate, implying different cancer aetiologies or evolutions …

Colorectal cancer is a complex disease resulting from somatic genetic and epigenetic
alterations, including locus-specific CpG island methylation and global DNA or LINE-1 …

Colorectal cancer (CRC) is a heterogeneous disease, arising from many possible etiological
pathways. This heterogeneity can have important implications for CRC prognosis and …

Colorectal cancer (CCR) is one of the most frequent cancers in developed countries. It
poses a major public health problem and there is renewed interest in understanding the …

Pathogenesis may be defined as the mechanism underlying the evolution of a disease state.
Like other types of neoplasia, colorectal cancer is now understood to be a genetic disorder …

Objective An understanding of the etiologic heterogeneity of colorectal cancer (CRC) is
critical for improving precision prevention, including individualized screening …

Despite significant progress in our understanding of the etiology, biology and genetics of
colorectal cancer, as well as important clinical advances, it remains the third most frequently …

Colorectal carcinoma is one of the most common cancers encountered in the western world
and increasingly in the developing world as well. This conditions results in considerable …

BACKGROUND Colorectal cancer, for many years a prototypic model for the genetic basis of
cancer, is now increasingly cited as an exemplar of the role of epigenetic changes in …

Abstract Purpose of Review Molecular pathways in colorectal carcinogenesis involve
several complex genetic and epigenetic modulations that cause normal colonic mucosa to …