Physical exercise has been established as a low-cost, safe, and effective way to manage
chronic intractable pain. We investigated the underlying mechanisms of exercise-induced …

It is well known that exercise produces analgesic effects (exercise-induced hypoalgesia
(EIH)) in animal models and chronic pain patients, but the brain mechanisms underlying …

Background Exercise alleviates pain and it is a central component of treatment strategy for
chronic pain in clinical setting. However, little is known about mechanism of this exercise …

Physical exercise has been established as a low-cost, safe, and effective way to manage
chronic pain, but exact mechanisms underlying such exercise-induced hypoalgesia (EIH) …

Ventral tegmental area (VTA) dopamine (DA) neurons are the primary source of dopamine
in target structures that constitute the mesolimbic reward system. Previous studies …

Exercise is an integral part of the rehabilitation of patients suffering a variety of chronic
musculoskeletal conditions, such as fibromyalgia, chronic low back pain and myofascial …

Background: Exercise is an effective treatment for various chronic pain disorders, including
fibromyalgia, chronic neck pain, osteoarthritis, rheumatoid arthritis, and chronic low back …

Background Physical exercise effectively attenuates neuropathic pain, and multiple events
including the inhibition of activated glial cells in the spinal dorsal horn, activation of the …

Physical exercise, such as forced treadmill running and swimming, can sufficiently improve
mechanical allodynia and heat hyperalgesia in animal models of neuropathic pain (NPP) …

Abstract Treatment of neuropathic pain is a clinical challenge likely because of the time-
dependent changes in many neurotransmitter systems, growth factors, ionic channels …