L'accumulation et la surstimulation des leucocytes neutrophiles (PMNs) et de la
myéloperoxydase (MPO), cellules et enzyme essentielles du système immunitaire, au sein …

Myeloperoxidase (MPO) is an important enzyme that catalyzes the reaction between
hydrogen peroxide and chloride to generate hypochlorous acid, which oxidizes a range of …

La myéloperoxydase (MPO) est une enzyme hémique présente en concentrations
importantes (±5% en poids) dans les granules primaires des cellules polymorphonucléaires …

In previous studies, propofol has shown immunomodulatory abilities on various in vitro
models. As this anesthetic molecule is extensively used in intensive care units, its anti …

The action of non-steroidal anti-inflammatory drugs (NSAIDS) has been ascribed to their
ability to block the reaction of arachidonate with cyclooxygenase/peroxidase, thus inhibiting …

Morphine is an opioid alkaloid commonly used in clinical practice for its analgesic
properties. The phenolic hydroxyl group of that phenanthrene derivative is pivotal for binding …

Drug metabolism is an essential process that chemically alters xenobiotic substrates to
activate or terminate drug activity. Myeloperoxidase (MPO) is a neutrophil-derived enzyme …

The powerful oxidant HOCl (hypochlorous acid and its corresponding anion,− OCl)
generated by the myeloperoxidase (MPO)–H 2 O 2–Cl− system of activated leukocytes is …

This thesis discusses the use of computational and experimental methods for the
development of new myeloperoxidase (MPO) inhibitors. MPO is a key enzyme present …

Objectives. To determine the antioxidant activities of nonsteroidal anti-inflammatory drugs
(NSAIDS), we examined by chemiluminescence (CL) and electron spin resonance (ESR) …