Dysregulation of glutathione homeostasis and alterations in glutathione-dependent enzyme
activities are increasingly implicated in the induction and progression of neurodegenerative …

There is significant evidence that the pathogenesis of several neurodegenerative diseases,
including Parkinson's disease, Alzheimer's disease, Friedreich's ataxia and amyotrophic …

Glutathione is a remarkably functional molecule with diverse features, which include being
an antioxidant, a regulator of DNA synthesis and repair, a protector of thiol groups in …

Altered glutathione metabolism in association with increased oxidative stress has been
implicated in the pathogenesis of many diseases. However, whether strategies aimed at …

Significance: Neurodegenerative diseases are characterized by progressive loss of
neurons. A common feature is oxidative stress, which arises when reactive oxygen species …

Glutathione (GSH) is an important antioxidant found abundantly and synthesized
intracellularly in the cytosol in a tightly regulated fashion. It has diverse physiological …

Glutathione is a storage form of cysteine and protects against reactive oxygen species and
potentially toxic xenobiotics in the central nervous system. Marked reductions in intracellular …

Redox dysfunctions and neuro-oxidative stress play a major role in the pathophysiology and
progression of Parkinson's disease (PD). Glutathione (GSH) and the reduced/oxidized …

Oxidative stress has been implicated in both normal aging and in various
neurodegenerative disorders and may be a common mechanism underlying various forms …

There is substantial agreement that the unbalance between oxidant and antioxidant species
may affect the onset and/or the course of a number of common diseases including …