Adolescence is a period of incredible change, especially within the brain's reward circuitry.
Stress, including social isolation, during this time has profound effects on behaviors …

Exposure to adversity during early childhood and adolescence increases an individual's
vulnerability to developing substance use disorder. Despite the knowledge of this …

Childhood and adolescent adversity are associated with a wide range of psychiatric
disorders, including an increased risk for substance abuse. Despite this, the mechanisms …

Adolescence is a developmental period associated with vast neural and behavioral changes
which are accompanied by altered sensitivity to stimuli, both stressful and rewarding …

Adolescent social isolation (SI) results in numerous behavioral alterations associated with
increased risk of alcoholism. Notably, many of these changes involve the basolateral …

Adolescence is a critical developmental period characterized by enhanced social
interactions, ongoing development of the frontal cortex and maturation of synaptic …

Early development is characterized by dynamic transitions in brain maturation, which may
be impacted by environmental factors. Here, we sought to determine the effects of social …

Chronic social isolation stress during adolescence induces susceptibility for
neuropsychiatric disorders. Here we show that 5-week post-weaning isolation stress …

Evolutionarily conserved, peer-directed social behaviors are essential to participate in many
aspects of human society. These behaviors directly impact psychological, physiological, and …

Background Sex differences in addiction have been described in humans and animal
models. A key factor that influences addiction in both males and females is adolescent …