Glial cell-derived neurotrophic factor (GDNF), and the neurotrophin nerve growth factor
(NGF) and brain-derived neurotrophic factor (BDNF) are important for the survival …

The concept of repairing the brain with growth factors has been pursued for many years in a
variety of neurodegenerative diseases including primarily Parkinson's disease (PD) using …

Parkinson's disease (PD) is a chronic, progressive neurodegenerative movement disorder
for which there is currently no effective therapy. Over the past several decades, there has …

Background: The search for therapeutic agents that might alter the disease course in
Parkinson's disease (PD) is ongoing. One area of particular interest involves neurotrophic …

The glial cell line-derived neurotrophic factor (GDNF) is a well-established trophic agent for
dopaminergic (DA) neurons in vitro and in vivo. GDNF is necessary for maintenance of …

Neurotrophic factors (NTFs) hold great potential as therapeutic agents in the treatment of
neurodegenerative conditions, including Parkinson's disease (PD), in which the progressive …

Neurotrophic factors (NTF) are a subgroup of growth factors that promote survival and
differentiation of neurons. Due to their neuroprotective and neurorestorative properties, their …

Abstract Changes in the levels and activities of neurotrophic factors, such as brain-derived
neurotrophic factor (BDNF), have been described in a number of neurodegenerative …

Brain Derived Neurotrophic Factor (BDNF) is a unique member of the neurotrophin family
with potent and plethoric effects on the proliferation, differentiation, survival and death of …

In a healthy adult brain, glial cell line-derived neurotrophic factor (GDNF) is exclusively
expressed by neurons, and, in some instances, it has also been shown to derive from a …