Frostbite, a debilitating condition, significantly affects the well-being of military veterans and
high-altitude residents, causing severe clinical complications such as chronic pain that …

Background Frostbite injury occurs when exposure to cold results in frozen tissue. To screen
drugs and other field therapies that might improve the outcome for a frostbite victim, it would …

Cold injury or frostbite is a common medical condition that causes serious clinical
complications including sensory abnormalities and chronic pain ultimately affecting overall …

Objectives Pathophysiologic changes of frostbite have been postulated but rarely
understood, especially the changes caused by chilly high altitude environment. Therefore …

Cold injuries and its sequelae has for decades, been a relevant problem and an
occupational hazard in the army, and continue to be so. These sequelae may hamper future …

Cold pain is a frequent symptom in neuropathic pain. Compared to other pain modalities,
such as heat pain, the mechanisms behind physiological and pathological cold pain remain …

Frostbite is tissue damage caused by freezing temperatures and constitutes an important
cause of morbidity in cold climate zones and high altitude. The direct effects of sub-zero …

High-altitude regions, cold deserts, permafrost regions, and the polar region have some of
the severest cold conditions on earth and pose immense perils of cold injuries to exposed …

Frostbite is a severe ischemic injury which occurs due to the tissue vascular damage after
sub-zero temperature tissue exposure. Deep frostbite can result in necrosis and may need …

Introduction Frostbite is thought to result from initial vasoconstriction, ischemia, intracellular
ice crystal formation, and inflammation caused by reperfusion injury. Corticosteroids have …