A rate-limiting step in the prevention and early intervention of depressive disorders in young
people is our insufficient understanding of causal mechanisms. One plausible …

Major mood syndromes are among the most common and disabling mental disorders.
However, a lack of clear delineation of their underlying pathophysiological mechanisms is a …

Circadian rhythms are internal manifestations of the solar day that permit adaptations to
predictable environmental temporal changes. These~ 24-h rhythms are controlled by …

Objective Sleep disturbances are highly frequent features in a range of child and adolescent
psychiatric conditions. However, it is commonly not clear if such sleep problems represent …

The clinical observations of diurnal variation of mood and early morning awakening in
depression have been incorporated into established diagnostic systems, as has the …

Sleep, circadian rhythms, and mental health are reciprocally interlinked. Disruption to the
quality, continuity, and timing of sleep can precipitate or exacerbate psychiatric symptoms in …

Background A long-standing challenge in the treatment of depression is the development of
a rapidly acting antidepressant. Conventional antidepressants typically require 2–8 weeks …

Evidence for the importance of sleep in the mood disorders has mushroomed over the past
decade. Among adolescents and adults with a mood disorder, sleep disturbance is a risk …

In humans, most physiological and behavioural functions demonstrate a circadian
rhythmicity, which is essential to adequately cope with dramatic fluctuations occurring in the …

The importance of time is ever prevalent in our world, and disruptions to the normal
light/dark and sleep/wake cycle have now become the norm rather than the exception for a …