Multiplex protein imaging in tumour biology
N de Souza, S Zhao, B Bodenmiller - Nature Reviews Cancer, 2024 - nature.com
Tissue imaging has become much more colourful in the past decade. Advances in both
experimental and analytical methods now make it possible to image protein markers in …
experimental and analytical methods now make it possible to image protein markers in …
Spatial omics and multiplexed imaging to explore cancer biology
Understanding intratumoral heterogeneity—the molecular variation among cells within a
tumor—promises to address outstanding questions in cancer biology and improve the …
tumor—promises to address outstanding questions in cancer biology and improve the …
Multiplex tissue imaging: spatial revelations in the tumor microenvironment
S van Dam, MJD Baars, Y Vercoulen - Cancers, 2022 - mdpi.com
Simple Summary Cancer is the leading cause of death worldwide, and the overall aging of
the population results in an increased risk of a cancer diagnosis during a person's lifetime …
the population results in an increased risk of a cancer diagnosis during a person's lifetime …
Optimizing multiplexed imaging experimental design through tissue spatial segregation estimation
Recent advances in multiplexed imaging methods allow simultaneous detection of dozens
of proteins and hundreds of RNAs, enabling deep spatial characterization of both healthy …
of proteins and hundreds of RNAs, enabling deep spatial characterization of both healthy …
Multiplexed imaging in oncology
In oncology, technologies for clinical molecular imaging are used to diagnose patients,
establish the efficacy of treatments and monitor the recurrence of disease. Multiplexed …
establish the efficacy of treatments and monitor the recurrence of disease. Multiplexed …
Multiplexed imaging of intracellular protein networks
Cellular functions emerge from the collective action of a large number of different proteins.
Understanding how these protein networks operate requires monitoring their components in …
Understanding how these protein networks operate requires monitoring their components in …
Spatial mapping of protein composition and tissue organization: a primer for multiplexed antibody-based imaging
Tissues and organs are composed of distinct cell types that must operate in concert to
perform physiological functions. Efforts to create high-dimensional biomarker catalogs of …
perform physiological functions. Efforts to create high-dimensional biomarker catalogs of …
Next-generation pathology using multiplexed immunohistochemistry: mapping tissue architecture at single-cell level
FM Bosisio, Y Van Herck, J Messiaen… - Frontiers in …, 2022 - frontiersin.org
Single-cell omics aim at charting the different types and properties of all cells in the human
body in health and disease. Over the past years, myriads of cellular phenotypes have been …
body in health and disease. Over the past years, myriads of cellular phenotypes have been …
High-plex imaging of RNA and proteins at subcellular resolution in fixed tissue by spatial molecular imaging
S He, R Bhatt, C Brown, EA Brown, DL Buhr… - Nature …, 2022 - nature.com
Resolving the spatial distribution of RNA and protein in tissues at subcellular resolution is a
challenge in the field of spatial biology. We describe spatial molecular imaging, a system …
challenge in the field of spatial biology. We describe spatial molecular imaging, a system …
[HTML][HTML] Next-generation pathology—surveillance of tumor microecology
B Koos, M Kamali-Moghaddam, L David… - Journal of molecular …, 2015 - Elsevier
A tumor is a heterogeneous population of cells that provides an environment in which every
cell resides in a microenvironmental niche. Microscopic evaluation of tissue sections, based …
cell resides in a microenvironmental niche. Microscopic evaluation of tissue sections, based …