Tissue imaging has become much more colourful in the past decade. Advances in both
experimental and analytical methods now make it possible to image protein markers in …

Understanding intratumoral heterogeneity—the molecular variation among cells within a
tumor—promises to address outstanding questions in cancer biology and improve the …

Simple Summary Cancer is the leading cause of death worldwide, and the overall aging of
the population results in an increased risk of a cancer diagnosis during a person's lifetime …

Recent advances in multiplexed imaging methods allow simultaneous detection of dozens
of proteins and hundreds of RNAs, enabling deep spatial characterization of both healthy …

In oncology, technologies for clinical molecular imaging are used to diagnose patients,
establish the efficacy of treatments and monitor the recurrence of disease. Multiplexed …

Cellular functions emerge from the collective action of a large number of different proteins.
Understanding how these protein networks operate requires monitoring their components in …

Tissues and organs are composed of distinct cell types that must operate in concert to
perform physiological functions. Efforts to create high-dimensional biomarker catalogs of …

Single-cell omics aim at charting the different types and properties of all cells in the human
body in health and disease. Over the past years, myriads of cellular phenotypes have been …

Resolving the spatial distribution of RNA and protein in tissues at subcellular resolution is a
challenge in the field of spatial biology. We describe spatial molecular imaging, a system …

A tumor is a heterogeneous population of cells that provides an environment in which every
cell resides in a microenvironmental niche. Microscopic evaluation of tissue sections, based …