Most cigarette smokers who wish to quit too often relapse within the first few days of
abstinence, primarily due to the aversive aspects of the nicotine withdrawal syndrome …

Nicotine dependence is a major predictor of relapse in people with Tobacco Use Disorder
(TUD). Accordingly, therapies that reduce nicotine dependence may promote sustained …

Context Understanding the mechanisms underlying nicotine addiction to develop more
effective treatment is a public health priority. Research consistently shows that nicotine …

The development of brain-based biomarkers to assess nicotine dependence severity and
treatment efficacy are essential to improve the current marginally effective treatment …

BACKGROUND: Cigarette smoking is the leading preventable cause of death.
Unfortunately, the majority of smokers who attempt to quit smoking relapse within weeks …

Introduction Perturbations in neural function provoked by a drug are thought to induce
neural adaptations, which, in the absence of the drug, give rise to withdrawal symptoms …

Currently available therapies for smoking cessation have limited efficacy, and potential
treatments that target specific brain regions are under evaluation, with a focus on the insula …

Background Long-term cigarette smoking induces sensitization of incentive salience and
conditioning of contextual cues which involves brain function alteration across multiple …

Smoking‐induced relief of craving and withdrawal promotes continued cigarette use.
Understanding how relief is produced and the role of nicotine in this process may facilitate …

The striatum is the critical area of reward processing and has been repeatedly linked to
nicotine addiction. However, it remains unclear whether different smoking cessation …