Ferroptosis is a type of iron-dependent cell death pertaining to an excess of lipid
peroxidation. It has been suggested that sorafenib—an anti-angiogenic medication for …

Sorafenib, a first-line drug for advanced hepatocellular carcinoma (HCC), shows a favorable
anti-tumor effect while resistance is a barrier impeding patients from benefiting from it. Thus …

Ferroptosis is a form of regulated, non‐apoptotic cell death characterized by excessive lipid
peroxidation that can be triggered by inhibition of the cystine‐glutamate antiporter, system …

Purpose Sorafenib is a multi-kinase inhibitor that is used as a standard treatment for
advanced hepatocellular carcinoma (HCC). However, the mechanism of sorafenib …

Background: Ferroptosis is a unique form of regulated cell death that provided a new
opportunity for cancer therapy. Ferroptosis suppressor protein 1 (FSP1) is a key regulator in …

Background Drug resistance to sorafenib greatly limited the benefits of treatment in patients
with hepatocellular carcinoma (HCC). MicroRNAs (miRNAs) participate in the development …

Abstract Sigma‐1 receptor (S1R) regulates reactive oxygen species (ROS) accumulation via
nuclear factor erythroid 2‐related factor 2 (NRF2), which plays a vital role in ferroptosis …

Poor sensitivity to sorafenib has been an important constraint on the efficacy of targeted
therapy in advanced hepatocellular carcinoma (HCC). Therefore, it is particularly important …

BACKGROUND: Secreted protein acidic and rich in cysteine (SPARC) is implicated in
cancer progression, but its role and associated molecular mechanism in the sorafenib …

Abstract Interferon-gamma (IFN-γ) exerts anti-tumor effects by inducing ferroptosis. Based on
CRISPR/Cas9 knockout screening targeting genome-wide protein encoding genes in …