Aneuploidy, or imbalanced chromosome number, has profound effects on eukaryotic cells.
In humans, aneuploidy is associated with various pathologies, including cancer, which …

Aneuploidy, a genomic alternation characterized by deviations in the copy number of
chromosomes, affects organisms from early development through to aging. Although it is a …

Unbalanced chromosome content, so‐called aneuploidy, is a hallmark of cancer cells.
Changes in the copy numbers of chromosomes or large chromosomal regions significantly …

Most solid human tumours are aneuploid, that is, they contain an abnormal number of
chromosomes. Paradoxically, however, aneuploidy has been reported to induce a stress …

Deviation from a balanced genome by either gain or loss of entire chromosomes is generally
tolerated poorly in all eukaryotic systems studied to date. Errors in mitotic or meiotic cell …

Aneuploidy is a characteristic of cancer, with greater than 90% of all solid tumors in humans
carrying an aberrant karyotype. Yet, whether or how this condition contributes to …

Aneuploidy is frequently associated with disease and developmental abnormalities. It is also
a key characteristic of cancer. Several model systems have been developed to study the role …

Aneuploidy, or an aberrant karyotype, results in developmental disabilities and has been
implicated in tumorigenesis. However, the causes of aneuploidy-induced phenotypes and …

Aneuploidy, a state of karyotype imbalance, is a hallmark of cancer. Changes in
chromosome copy number have been proposed to drive disease by modulating the dosage …

Cancer is driven by multiple types of genetic alterations, which range in size from point
mutations to whole-chromosome gains and losses, known as aneuploidy. Chromosome …