To evaluate the mechanism of fluoride (F) mitochondrial toxicity, we cultured Hepa1-6 cells
with different F concentrations (0, 1 and 2 mmoL/L) and determined cell pathological …

Our previous study showed that excessive fluoride (F) intake can induce liver dysfunction.
The aim of this study was to investigate the mechanisms of F-induced mitochondrial damage …

This study was designed to investigate the mechanisms of excessive fluoride-induced
apoptosis via mitochondria-mediated pathway in skeletal muscle cells (C2C12 cells) …

Excessive fluoride intake has a strong female reproductive toxicity, which can result in
follicular developmental dysplasia and decrease oocytes developmental potential. The …

Fluoride, a toxic substance, is widely distributed in the environment and causes serious
damage to the body. This study was performed to investigate the effects of fluoride on …

Fluoride is ubiquitous in the environment. Furthermore, drinking water represents the main
source of exposure to fluoride for humans. Interestingly, low fluoride concentrations have …

A fluoride exposure mouse model is established to evaluate the relationship between
mitochondrial respiratory chain complexes and renal dysfunction. Morphological changes in …

Studies focusing on possible genotoxic effects of excess fluoride are contradictory and
inconclusive. Currently, studies have reported a probable link to oxidative stress, DNA …

Fluoride is commonly found in the soil and water environment and may act as chronic
poison. A large amount of fluoride deposition causes serious harm to the ecological …

The mechanisms involved in changes in energy metabolism caused by excessive exposure
to fluoride (F) are not completely understood. The present study employed proteomic tools to …