Susceptibility to multiple sclerosis (MS) is associated with the human histocompatibility
leukocyte antigen (HLA)-DR2 haplotype, suggesting that major histocompatibility complex …

In this study, we evaluated the role of the two functional HLA-DR heterodimers, DR2a (DRα
paired with the β chain encoded by DRB5* 0101) and DR2b (DRα paired with the β chain …

The pathogenesis of multiple sclerosis (MS) is currently ascribed in part to a T cell-mediated
process targeting myelin components. The T cell response to one candidate autoantigen …

Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the CNS. The
numbers of autoimmune T cells and Abs specific for proteins of CNS myelin are increased in …

Autoreactive T cells of CD4 and CD8 subsets recognizing myelin basic protein (MBP), a
candidate myelin autoantigen, are thought to contribute to and play distinct roles in the …

We have examined previously the peptide specificity of the T cell response to myelin basic
protein (MBP) in patients with multiple sclerosis (MS) and healthy controls, and …

A panel of 90 myelin basic protein (MBP)‐specific T‐cell lines were derived from peripheral
blood of eight patients with multiple sclerosis and four normal subjects. The precursor …

Susceptibility to multiple sclerosis (MS) is associated with certain MHC class II haplotypes, in
particular HLA-DR2. Two DR β chains, DRB1∗ 1501 and DRB5∗ 0101, are co-expressed in …

T lymphocytes from patients with multiple sclerosis (MS) recognize multiple myelin basic
protein (MBP) epitopes. This situation complicates the design of specific immunotherapies …

A panel of 20 human myelin basic protein (hMBP)-specific T-lymphocyte lines was
generated from the peripheral blood of eight multiple sclerosis (MS) patients and two healthy …