Cells in different tissues, including endocrine cells in the pancreas, live in complex
microenvironments that are rich in cellular and acellular components. Intricate interactions …

The progressive loss of pancreatic β‐cell mass that occurs in both type 1 and type 2
diabetes is a primary factor driving efforts to identify strategies for effectively increasing …

Endocrine cells within the pancreatic islets of Langerhans are heterogeneous in terms of
transcriptional profile, protein expression and the regulation of hormone release. Even …

Pancreatic β-cells perform glucose-stimulated insulin secretion, a process at the center of
type 2 diabetes etiology. Efforts to understand how β-cells behave in healthy and stressful …

Pancreatic beta cells play a critical role in maintaining glucose homeostasis by serving as
the primary source of insulin. These cells are responsible for the synthesis, storage, and …

Summary Recent studies in Type 1 Diabetes (T1D) support an emerging model of disease
pathogenesis that involves intrinsic β-cell fragility combined with defects in both innate and …

AIM: There is growing evidence that the beta-cell is central to the development of Type 2
diabetes. In this brief review we discuss the factors predisposing to beta-cell dysfunction and …

Abstract β cells uniquely produce and secrete insulin under the control of several, integrated
signals, to maintain blood glucose concentrations within a narrow physiological interval. β …

Although β-cell heterogeneity was discovered more than 50 years ago, the underlying
principles have been explored only during the past decade. Islet-cell heterogeneity arises …

In type 1 diabetes (T1D) β cell mass is markedly reduced by autoimmunity. Type 2 diabetes
(T2D) results from inadequate β cell mass and function that can no longer compensate for …