The central adenosine system and adenosine receptors play a fundamental role in the
modulation of dopaminergic neurotransmission. This is mostly achieved by the strategic co …

In the striatum, adenosine A2A receptors (A2AR) are mainly expressed within the soma and
dendrites of the striatopallidal neuron. A predominant proportion of these striatal …

Striatal dopamine adenosine A2A and D2 receptors interact to modulate some aspects of
motor and motivational function. The demonstration of A2A/D2 receptor heteromerization in …

Adenosine A2A (A2AR) and dopamine D2 (D2R) receptors mediate the antagonism
between adenosinergic and dopaminergic transmission in striatopallidal GABAergic …

The existence of A 2A-D 2 heteromeric complexes is based on coimmunoprecipitation
studies and on fluorescence resonance energy transfer and bioluminescence resonance …

A very significant density of adenosine A2A receptors (A2ARs) is present in the striatum,
where they are preferentially localized postsynaptically in striatopallidal medium spiny …

Adenosine–dopamine interactions in the central nervous system (CNS) have been studied
for many years in view of their relevance for disorders of the CNS and their treatments. The …

Dopamine receptor subtypes D1 and D2, and many other seven-transmembrane receptors
including adenosine receptor A2A, are colocalized in striatum of brain. These receptors …

Adenosine receptors are G protein-coupled receptors (GPCRs) that mediate the
physiological functions of adenosine. In the central nervous system adenosine A2A …

The dopamine D1 and D2 receptors are major receptors in the regulation of striatal function
and striatal adenosine A1 and A2A receptors are major modulators of their signaling. The …