Cryptococcus neoformans and distantly related fungal species release extracellular vesicles
that traverse the cell wall and contain a varied assortment of components, some of which …

Cryptococcus neoformans produces vesicles containing its major virulence factor, the
capsular polysaccharide glucuronoxylomannan (GXM). These vesicles cross the cell wall to …

Cryptococcus neoformans produces extracellular vesicles containing a variety of cargo,
including virulence factors. To become extracellular, these vesicles not only must be …

A remarkable aspect of the interaction of Cryptococcus neoformans with mammalian hosts is
a consistent increase in capsule volume. Given that many aspects of the interaction of C …

Cryptococcus neoformans (CN), an encapsulated, ubiquitous environmental yeast, is
pathogenic for humans, primarily those with compromised immune function. CN is believed …

Despite a presumed critical role of macrophages in the host response to cryptococcal
infections, previous studies have failed to show growth inhibition of encapsulated …

Cryptococcus neoformans is an encapsulated yeast that causes systemic mycosis in
immunosuppressed individuals. Recent studies have determined that this fungus produces …

Background The interaction between macrophages and Cryptococcus neoformans (Cn) is
critical for containing dissemination of this pathogenic yeast. However, Cn can either lyse …

The antiphagocytic polysaccharide capsule of the human fungal pathogen Cryptococcus
neoformans is a major virulence attribute. However, previous studies of the pleiotropic …

The capsule is closely associated with the virulence of Cryptococcus neoformans. The
capsule inhibits phagocytosis by macrophages, monocytes, and neutrophils. Studies in our …