With the goal of developing potential cholinesterase pharmaco-therapeutics, a new class of
thirty analogs oxindole-based chalcone were synthesized by reacting nitro substituted …

Alzheimer's disease is a neurological disorder characterized by cognitive dysfunction and
deficits in activities of daily living. There is no drug available for Alzheimer's at the moment …

The design of an acetylcholinesterase inhibitor with multifunctional properties became the
perspective for the development of an effective drug against Alzheimer's disease. Towards …

In synthetic medicinal chemistry thiophene and their analogues play a vital role due to the
wide range of pharmacological properties. In current studies, we have synthesized a new …

Acetylcholinesterase inhibitors (AChEIs) have become a significant target in the search for
an efficient treatment of Alzheimer's disease. Chalcone-based compounds display a strong …

Acetylcholinesterase prevails in the healthy brain, with butyrylcholinesterase reflected to
play a minor role in regulating brain acetylcholine (ACh) levels. However, BuChE activity …

A new series of benzylaminochalcone derivatives with different substituents on ring B were
synthesized and evaluated as inhibitors of acetylcholinesterase. The study is aimed at …

Alzheimer's disease (AD) is treated by targeting cholinesterase enzymes like
acetylcholinesterase and butyrylcholinesterase, and these enzymes' inhibitors serve as …

A new series of‐fluoro chalcones‐substituted amino‐alkyl derivatives (3a˜ 3l) were
designed, synthesized, characterized and evaluated for the inhibitory activity against …

A new series of benzimidazole-based thiadiazole hybrids analogues (6a–p) as effective
Alzheimer's inhibitors were synthesized and then evaluated for their inhibition profile against …