The prevalence of obesity continues to rise worldwide despite evidence-based public health
recommendations. The promise to adopt a healthy lifestyle is increasingly important for …

The prevalence of diabetes and obesity continues to increase. It is therefore important to
identify the pathophysiology underlying these disorders. An inability of insulin to stimulate …

Adipokines, or adipose tissue-derived cytokines/proteins, may be important factors linking
excess adipose tissue to individual metabolic risk factors, and the overall metabolic …

From the perspective of a muscle physiologist, adipose tissue has long been perceived
predominantly as a fuel reservoir that provides muscle and other tissues with NEFA when …

Obesity has reached global epidemic proportions and is threatening the economic
sustainability of the health care system of many countries worldwide. This is related largely …

Emerging evidence suggests a significant functional role of adipose tissue in maintaining
whole-body metabolic health. It is well established that obesity leads to compositional and …

Obesity represents a significant public health concern with one-third of adults classified as
living with obesity in the United States. It correlates with cardio-metabolic comorbidities that …

Recent discoveries, notably of the hormones leptin and adiponectin, have revised the notion
that adipocytes are simply a storage depot for body energy. Instead, adipocytes are also …

Obesity is a major public health problem in the twenty-first century. Mutations in genes that
regulate substrate metabolism, subsequent dysfunction in their protein products, and other …

Obesity is recognized as a risk factor for lifestyle‐related diseases such as type 2 diabetes
and cardiovascular disease. White adipose tissue (WAT) is not only a static storage site for …