Radio-and chemotherapy are the most common cancer treatment modalities. They cause
acute and late side effects on normal tissues, which is a burden for delivery of a high dose of …

Leukaemia is a dangerous malignancy that causes thousands of deaths every year
throughout the world. The rate of morbidity and mortality is significant despite many …

Melatonin, an indolamine derived from the amino-acid tryptophan, participates in diverse
physiological functions and has great functional versatility related to the regulation of …

Introduction: Compelling evidence has highlighted the complex pleiotropic functions elicited
by the melatonin in cancer cells. Melatonin behaves as a 'smart killer', ie, modulating anti …

Melatonin is an indolamine initially found to be produced in the pineal gland but now known
to be synthesized in a variety of other tissues as well. The mechanisms whereby melatonin …

Melatonin is a natural compound synthesized by a variety of organs. It has been shown to
function as a cell-protective agent. Since 1994, when the first paper was published …

It is well established that melatonin exerts antitumoral effects in many cancer types, mostly
decreasing cell proliferation at low concentrations. On the other hand, induction of apoptosis …

The role of melatonin in the mediation of apoptotic events has recently gained attention,
especially after recent studies have reported that melatonin exerts antiapoptotic actions in …

Background Melatonin has antitumor activity via several mechanisms including its
antiproliferative and proapoptotic effects in addition to its potent antioxidant actions …

Cancer remains among the most challenging human diseases. Several lines of evidence
suggest that carcinogenesis is a complex process that is initiated by DNA damage …