Discussion DR. RANDALL M. ZUSMAN (Director, Hypertension Division, Cardiac Unit,
Massachusetts General Hospital, and Assistant Professor of Medicine, Harvard Medical …

Careful scrutiny of scientific records can show that the connection between the kidney and
hypertension had been discovered early in the 19th century, but undoubtedly it is the …

Thomas Unger and Peter Gohlke he renin-angiotensin system (fig I) is a major
cardiovascular control mechanism. The ingenious T induction of secondary hypertension in …

The renin-angiotensin-aldosterone system plays an integral role in the control of BP and is
mediated by enzymatic transformation of substances in the renin-angiotensin cascade …

The renin-angiotensin system is one of the humoral mechanisms involved in the regulation
of blood pressure. Even though thepreliminary investigations can be traced as far back as …

The beginning of the 1980s may well be remembered as a turning point in the treatment of
hypertension, one of the most common of man's afflictions.'In 1980 and 1981, the first …

Although the role of the renin-angiotensin system in the pathogenesis of hypertension
remains a subject of active investigation and debate, there is increasing recognition that …

We review information on the renal response to converting enzyme inhibition, and attempt to
evaluate the evidence that a reduction in angiotensin II formation is responsible for the renal …

The importance of the renin-angiotensin system (RAS) in blood pressure (BP) regulation
and sodium homeostasis has been revealed by extensive experimental and clinical studies …

Several different strategies have been followed to block the activity of renin, the enzyme
catalyzing the first and rate-limiting step in the renin-angiotensin cascade. The unique …