Roxadustat for SARS-CoV-2 infection: old signaling raised new hopes
L Alkazmi, HM Al-Kuraishy, GES Batiha… - Drugs in R&D, 2022 - Springer
Roxadustat (RXT)(4-hydroxyl-1-methyl-7-phenoxyisoquinoline-3-caboxylic acid)(Fig. 1) is
an orally active prolyl hydroxylase (PHD) inhibitor that increases production of endogenous …
an orally active prolyl hydroxylase (PHD) inhibitor that increases production of endogenous …
[HTML][HTML] Long-term efficacy, safety, and medication compliance of roxadustat on peritoneal dialysis patients with renal anemia affected by the COVID-19 pandemic: a …
L Bao, X Bian, A Zhang, J Huang… - Annals of Palliative …, 2022 - apm.amegroups.org
Background: Current studies have limited data on long-term treatment safety and medication
compliance of roxadustat for renal anemia in peritoneal dialysis (PD) patients. We aimed to …
compliance of roxadustat for renal anemia in peritoneal dialysis (PD) patients. We aimed to …
Hypoxic and pharmacological activation of HIF inhibits SARS-CoV-2 infection of lung epithelial cells
COVID-19, caused by the novel coronavirus SARS-CoV-2, is a global health issue with more
than 2 million fatalities to date. Viral replication is shaped by the cellular microenvironment …
than 2 million fatalities to date. Viral replication is shaped by the cellular microenvironment …
Safe and effective treatment for anemic patients with chronic kidney disease: an updated systematic review and meta-analysis on roxadustat
M Tang, C Zhu, T Yan, Y Zhou, Q Lv… - Frontiers in …, 2021 - frontiersin.org
Background: Roxadustat is a new oral drug for anemia in chronic kidney disease (CKD).
This study aimed to synthesize the evidence from randomized controlled trial (RCT)-based …
This study aimed to synthesize the evidence from randomized controlled trial (RCT)-based …
Safety and efficacy of roxadustat for anemia in patients with chronic kidney disease: a meta-analysis and trial sequential analysis
C Liu, Z Fu, J Jiang, K Chi, X Geng, Z Mao… - Frontiers in …, 2021 - frontiersin.org
Background: Roxadustat, a hypoxia-inducible factor prolyl-hydroxylase inhibitor (HIF-PHI),
has been used to treat anemia in patients with chronic kidney disease (CKD). However, its …
has been used to treat anemia in patients with chronic kidney disease (CKD). However, its …
[HTML][HTML] Safety and effectiveness of roxadustat in dialysis-dependent patients with renal anemia: a hospital-based cohort study
O Moussa, C Feng, JX Wang, XS Li, FX Zhang… - Cureus, 2022 - ncbi.nlm.nih.gov
Background Randomized controlled trials (RCTs) have shown the efficacy and safety of
Roxadustat and conclude that it has the potential to change the treatment for anemia …
Roxadustat and conclude that it has the potential to change the treatment for anemia …
Efficacy and safety of roxadustat for anaemia in dialysis‐dependent and non‐dialysis‐dependent chronic kidney disease patients: A systematic review and meta …
L Zheng, J Tian, D Liu, Y Zhao, X Fang… - British journal of …, 2022 - Wiley Online Library
Aims Renal anaemia is a common complication of chronic kidney disease (CKD).
Roxadustat is the first‐in‐class oral hypoxia‐inducible factor prolyl hydroxylase inhibitor for …
Roxadustat is the first‐in‐class oral hypoxia‐inducible factor prolyl hydroxylase inhibitor for …
[HTML][HTML] Effectiveness and safety of roxadustat in the treatment of anemia of kidney disease: a systematic review and meta-analysis
H Wang, K Huang, C Wang, C Chen… - Annals of Palliative …, 2021 - apm.amegroups.org
Background: Chronic kidney disease is a global public health problem, anemia is the most
common complication of chronic kidney disease. Roxadustat is a new drug that can be used …
common complication of chronic kidney disease. Roxadustat is a new drug that can be used …
The DHODH inhibitor PTC299 arrests SARS-CoV-2 replication and suppresses induction of inflammatory cytokines
Abstract The coronavirus disease 2019 (COVID-19) pandemic has created an urgent need
for therapeutics that inhibit the SARS− COV-2 virus and suppress the fulminant inflammation …
for therapeutics that inhibit the SARS− COV-2 virus and suppress the fulminant inflammation …
[HTML][HTML] The efficacy of Roxadustat for the treatment of anemia in dialysis dependent chronic kidney disease patients: an updated systematic review and meta-analysis …
Background Anemia is a common complication in chronic kidney disease (CKD) with
increased morbidity and mortality. Recently published RCTs were conducted to compare the …
increased morbidity and mortality. Recently published RCTs were conducted to compare the …