The reproductive neuroendocrine system is a key target for the developmental programming
effects of steroid hormones during early life. While gonadal steroids play an important role in …

Prenatal testosterone (T) treatment recapitulates the reproductive and metabolic phenotypes
of polycystic ovary syndrome in female sheep. At the neuroendocrine level, prenatal T …

The susceptibility of the reproductive system to early exposure to steroid hormones has
become a major concern in our modern societies. Human fetuses are at risk of abnormal …

Background Prenatal testosterone (T) excess results in reproductive and metabolic
perturbations in female sheep that closely recapitulate those seen in women with polycystic …

Polycystic ovary syndrome (PCOS) is a complex disorder that results from a combination of
multiple factors, including genetic, epigenetic, and environmental influences. Evidence from …

Prenatal testosterone excess leads to neuroendocrine, ovarian, and metabolic disruptions,
culminating in reproductive phenotypes mimicking that of women with polycystic ovary …

Polycystic ovary syndrome (PCOS) is a fertility disorder affecting 5–7% of reproductive-aged
women. Women with PCOS manifest both reproductive and metabolic defects. Several …

Polycystic ovary syndrome (PCOS) is a major cause of reproductive and metabolic
dysfunction in women, but it remains an enigmatic condition whose treatment is necessarily …

Polycystic ovary syndrome (PCOS) is one of the most common fertility disorders, affecting
several million women worldwide. Women with PCOS manifest neuroendocrine, ovarian …

Polycystic ovarian syndrome (PCOS) is the leading cause of infertility in reproductive-aged
women with the majority manifesting insulin resistance. To delineate the causes of insulin …