Pathogenic alterations in PIK3CA and KMT2C are frequent and independent prognostic factors in anal squamous cell carcinoma treated with salvage …
A Hamza, J Masliah‐Planchon… - … Journal of Cancer, 2024 - Wiley Online Library
The management of anal squamous cell carcinoma (ASCC) has yet to experience the
transformative impact of precision medicine. Conducting genomic analyses may uncover …
transformative impact of precision medicine. Conducting genomic analyses may uncover …
[HTML][HTML] Mutational analysis of anal cancers demonstrates frequent PIK3CA mutations associated with poor outcome after salvage abdominoperineal resection
W Cacheux, E Rouleau, A Briaux, P Tsantoulis… - British journal of …, 2016 - nature.com
Background: A better understanding of the molecular profile of anal squamous cell
carcinomas (ASCCs) is necessary to consider new therapeutic approaches, and the …
carcinomas (ASCCs) is necessary to consider new therapeutic approaches, and the …
[HTML][HTML] Comparison of clinicopathological and genomic profiles in anal squamous cell carcinoma between Japanese and Caucasian cohorts
T Ito, D Takayanagi, S Sekine, T Hashimoto… - Scientific reports, 2023 - nature.com
Anal squamous cell carcinoma (ASCC) is a rare tumor of the gastrointestinal tract. We aimed
to compare the genetic backgrounds and their effect on clinical outcomes between …
to compare the genetic backgrounds and their effect on clinical outcomes between …
[HTML][HTML] Exome sequencing reveals aberrant signalling pathways as hallmark of treatment-naive anal squamous cell carcinoma
W Cacheux, V Dangles-Marie, E Rouleau… - Oncotarget, 2018 - ncbi.nlm.nih.gov
Anal squamous cell carcinomas (ASCC) are rare tumours in humans. The etiological role of
HPV infection is now well established but little is known about the molecular landscape and …
HPV infection is now well established but little is known about the molecular landscape and …
[HTML][HTML] Comprehensive genomic profiling of anal squamous cell carcinoma reveals distinct genomically defined classes
JH Chung, E Sanford, A Johnson, SJ Klempner… - Annals of …, 2016 - Elsevier
Background Squamous cell cancers of the anal canal (ASCC) are increasing in frequency
and lack effective therapies for advanced disease. Although an association with human …
and lack effective therapies for advanced disease. Although an association with human …
[HTML][HTML] Molecular and genomic characterisation of a panel of human anal cancer cell lines
Anal cancer is a rare disease that has doubled in incidence over the last four decades.
Current treatment and survival of patients with this disease has not changed substantially …
Current treatment and survival of patients with this disease has not changed substantially …
Array comparative genomic hybridization identifies high level of PI3K/Akt/mTOR pathway alterations in anal cancer recurrences
W Cacheux, P Tsantoulis, A Briaux, S Vacher… - Cancer …, 2018 - Wiley Online Library
Genomic alterations of anal squamous cell carcinoma (ASCC) remain poorly understood
due to the rarity of this tumor. Array comparative genomic hybridization and targeted gene …
due to the rarity of this tumor. Array comparative genomic hybridization and targeted gene …
Comprehensive genomic profiling of metastatic squamous cell carcinoma of the anal canal
Squamous cell carcinoma of the anal canal (SCCA) is a rare gastrointestinal malignancy
with an increasing annual incidence globally. The majority of cases are linked to prior …
with an increasing annual incidence globally. The majority of cases are linked to prior …
[HTML][HTML] Biomarkers in anal cancer: current status in diagnosis, disease progression and therapeutic strategies
MC Mathias-Machado, RDA Peixoto, CMV Moniz… - Biomedicines, 2022 - mdpi.com
Squamous cell carcinoma of the anal canal (SCCA) is a rare neoplasm, but with rising
incidence rates in the past few decades; it is etiologically linked with the human …
incidence rates in the past few decades; it is etiologically linked with the human …
Genomic evolution after chemoradiotherapy in anal squamous cell carcinoma
KW Mouw, JM Cleary, B Reardon, J Pike… - Clinical Cancer …, 2017 - AACR
Purpose: Squamous cell carcinoma of the anal canal (ASCC) accounts for 2% to 4% of
gastrointestinal malignancies in the United States and is increasing in incidence; however …
gastrointestinal malignancies in the United States and is increasing in incidence; however …