Chemical design and synthesis of functionalized probes for imaging and treating tumor hypoxia

J Liu, W Bu, J Shi - Chemical reviews, 2017 - ACS Publications
Hypoxia development in tumor is closely associated with its increased aggressiveness and
strong resistance to therapy, leading to the poor prognosis in several cancer types …

Designing Hypoxia‐Responsive Nanotheranostic Agents for Tumor Imaging and Therapy

H Zhou, F Qin, C Chen - Advanced Healthcare Materials, 2021 - Wiley Online Library
Hypoxia, a common feature of most solid tumors, plays an important role in tumor
proliferation, metastasis, and invasion, leading to drug, radiation, and photodynamic therapy …

Modulating hypoxia via nanomaterials chemistry for efficient treatment of solid tumors

Y Liu, Y Jiang, M Zhang, Z Tang, M He… - Accounts of Chemical …, 2018 - ACS Publications
Conspectus The common existence of hypoxia in solid tumors has been heavily researched
because it renders tumors more resistant to most standard therapeutic methods, such as …

Nano versus molecular: Optical imaging approaches to detect and monitor tumor hypoxia

MHY Cheng, Y Mo, G Zheng - Advanced Healthcare Materials, 2021 - Wiley Online Library
Hypoxia is a ubiquitous feature of solid tumors, which plays a key role in tumor angiogenesis
and resistance development. Conventional hypoxia detection methods lack continuous …

Hypoxia-responsive nanocarriers for cancer imaging and therapy: recent approaches and future perspectives

T Thambi, JH Park, DS Lee - Chemical Communications, 2016 - pubs.rsc.org
Hypoxia, a condition in which the tissue is deprived of adequate oxygen supply, is a salient
feature of various intractable diseases, including rheumatoid arthritis, ischemic stroke, and …

Nanomedicine strategies in conquering and utilizing the cancer hypoxia environment

Y Pan, L Liu, X Mou, Y Cai - ACS nano, 2023 - ACS Publications
Cancer with a complex pathological process is a major disease to human welfare. Due to
the imbalance between oxygen (O2) supply and consumption, hypoxia is a natural …

A new strategy toward “simple” water‐soluble AIE probes for hypoxia detection

C Xu, H Zou, Z Zhao, P Zhang… - Advanced Functional …, 2019 - Wiley Online Library
Hypoxia‐responsive fluorescent probes have emerged as a novel scaffold for tumor
diagnosis. However, dilemma often exists between simple synthesis and high water …

Hypoxia-triggered self-assembly of ultrasmall iron oxide nanoparticles to amplify the imaging signal of a tumor

H Zhou, M Guo, J Li, F Qin, Y Wang, T Liu… - Journal of the …, 2021 - ACS Publications
Hypoxia is a common phenomenon among most solid tumors that significantly influences
tumor response toward chemo-and radiotherapy. Understanding the distribution and extent …

Advanced nanomaterials for hypoxia tumor therapy: challenges and solutions

A Sundaram, L Peng, L Chai, Z Xie, JS Ponraj, X Wang… - Nanoscale, 2020 - pubs.rsc.org
In recent years, nanomaterials and nanotechnology have emerged as vital factors in the
medical field with a unique contribution to cancer medicine. Given the increasing number of …

Hypoxia-active nanoparticles used in tumor theranostic

Y Wang, W Shang, M Niu, J Tian… - International journal of …, 2019 - Taylor & Francis
Hypoxia is a hallmark of malignant tumors and often correlates with increasing tumor
aggressiveness and poor treatment outcomes. Therefore, early diagnosis and effective …