The mitotic checkpoint is a major cell cycle control mechanism that guards against
chromosome missegregation and the subsequent production of aneuploid daughter cells …

Aneuploidy has been recognized as a common characteristic of cancer cells for> 100 years.
Aneuploidy frequently results from errors of the mitotic checkpoint, the major cell cycle …

Abnormal chromosome content—also known as aneuploidy—is the most common
characteristic of human solid tumours. It has therefore been proposed that aneuploidy …

The cell cycle is a complex sequence of events through which a cell duplicates its contents
and divides, and involves many regulatory proteins for proper cellular reproduction …

Aneuploidy is frequently associated with disease and developmental abnormalities. It is also
a key characteristic of cancer. Several model systems have been developed to study the role …

Aneuploidy, an aberrant number of chromosomes, has been recognized as a feature of
human malignancies for over a century, but compelling evidence for causality was largely …

Aneuploidy, an abnormal number of chromosomes, is a trait shared by most solid tumors.
Chromosomal instability (CIN) manifested as aneuploidy might promote tumorigenesis and …

Aneuploidy is a prominent phenotype of cancer. It refers to deviations from the normal
number of chromosomes in a cell, as a result of whole-chromosome loss or gain. In most …

The improper distribution of chromosomes during mitosis compromises cellular functions
and can reduce cellular fitness or contribute to malignant transformation. As a …

Cancer is driven by multiple types of genetic alterations, which range in size from point
mutations to whole-chromosome gains and losses, known as aneuploidy. Chromosome …