Single-nucleus transcriptomics of the prefrontal cortex in major depressive disorder implicates oligodendrocyte precursor cells and excitatory neurons
Major depressive disorder (MDD) has an enormous impact on global disease burden,
affecting millions of people worldwide and ranking as a leading cause of disability for almost …
affecting millions of people worldwide and ranking as a leading cause of disability for almost …
Cell type specific transcriptomic differences in depression show similar patterns between males and females but implicate distinct cell types and genes
Major depressive disorder (MDD) is a common, heterogenous, and potentially serious
psychiatric illness. Diverse brain cell types have been implicated in MDD etiology …
psychiatric illness. Diverse brain cell types have been implicated in MDD etiology …
Integrating spatial and single-nucleus transcriptomic data elucidates microglial-specific responses in female cynomolgus macaques with depressive-like behaviors
J Wu, Y Li, Y Huang, L Liu, H Zhang, C Nagy… - Nature …, 2023 - nature.com
Major depressive disorder represents a serious public health challenge worldwide;
however, the underlying cellular and molecular mechanisms are mostly unknown. Here, we …
however, the underlying cellular and molecular mechanisms are mostly unknown. Here, we …
Convergent molecular, cellular, and cortical neuroimaging signatures of major depressive disorder
Major depressive disorder emerges from the complex interactions of biological systems that
span genes and molecules through cells, networks, and behavior. Establishing how …
span genes and molecules through cells, networks, and behavior. Establishing how …
Gene expression profiling in postmortem prefrontal cortex of major depressive disorder
Investigations of the molecular mechanisms underlying major depressive disorder (MDD)
have been hampered by the complexity of brain tissue and sensitivity of gene expression …
have been hampered by the complexity of brain tissue and sensitivity of gene expression …
Altered neuro-inflammatory gene expression in hippocampus in major depressive disorder
Abstract Major Depressive Disorder (MDD) is a common psychiatric disorder for which
available medications are often not effective. The high prevalence of MDD and modest …
available medications are often not effective. The high prevalence of MDD and modest …
Large-scale transcriptomics studies provide insight into sex differences in depression
Major depressive disorder (MDD) is a leading cause of disability, affecting more than 300
million people worldwide. We first review the well-known sex difference in incidence of …
million people worldwide. We first review the well-known sex difference in incidence of …
Cortical structural differences in major depressive disorder correlate with cell type-specific transcriptional signatures
Major depressive disorder (MDD) has been shown to be associated with structural
abnormalities in a variety of spatially diverse brain regions. However, the correlation …
abnormalities in a variety of spatially diverse brain regions. However, the correlation …
Depression: what we can learn from postmortem studies
G Rajkowska - The Neuroscientist, 2003 - journals.sagepub.com
The existence of depression has been recognized for decades, but its precise
neurobiological basis remains unknown. Whereas neuroimaging studies unravel the gross …
neurobiological basis remains unknown. Whereas neuroimaging studies unravel the gross …
Transcriptional profiling reveals evidence for signaling and oligodendroglial abnormalities in the temporal cortex from patients with major depressive disorder
C Aston, L Jiang, BP Sokolov - Molecular psychiatry, 2005 - nature.com
Major depressive disorder is one of the most common and devastating psychiatric disorders.
To identify candidate mechanisms for major depressive disorder, we compared gene …
To identify candidate mechanisms for major depressive disorder, we compared gene …