Renal cell carcinoma (RCC) is a constellation of malignancies of different histological
subtypes arising from the renal parenchyma. The clear cell histological subtype (ccRCC) …

Clear cell renal cell carcinoma (ccRCC) is the major subtype of kidney cancer that is
characterized by frequent inactivation of the von Hippel-Lindau (VHL) gene in 80–90% of …

BACKGROUND: Historically, VHL was the only frequently mutated gene in clear cell renal
cell carcinoma (ccRCC), with conflicting clinical relevance. Recent sequencing efforts have …

Renal cell carcinoma (RCC) is characterized by an infrequent number of somatic mutations.
By contrast, epigenetic aberrations are commonly found in RCC, indicating that epigenetic …

Purpose Clear cell, papillary cell, and chromophobe renal cell carcinomas (RCCs) have
now been well characterised thanks to large collaborative projects such as The Cancer …

Bi-allelic inactivation of the VHL gene on chromosome 3p is the characteristic feature in
most clear cell renal cell carcinomas (ccRCC). Frequent gene alterations were also …

Renal cell cancer (RCC) involves three most recurrent sporadic types: clear-cell RCC (70–
75%, CCRCC), papillary RCCC (10–15%, PRCC), and chromophobe RCC (5%, CHRCC) …

What's known on the subject? and What does the study add? Sporadic clear cell Renal Cell
Carcinoma (ccRCC) is dominated by nutations of the VHL gene located on chromosome 3p …

Abstract Although von Hippel‐Lindau (VHL) tumor suppressor gene alterations dominate the
genetic landscape of clear cell renal cell carcinoma (ccRCC), recent studies have identified …

Renal cell carcinoma (RCC) represents a heterogenous group of cancers with complex
genetic background and histological varieties, which require various clinical therapies. Clear …