The poor prognosis for patients with aggressive or metastatic tumors and the toxic side
effects of currently available treatments necessitate the development of more effective tumor …

Gene therapy is a novel means of anticancer treatment that has led to preliminary positive
results in the preclinical setting, as well as in clinical trials; however, successful clinical …

The attractiveness of prodrug cancer gene therapy by stem cells targeted to tumors lies in
activating the prodrug directly within the tumor mass, thus avoiding systemic toxicity. Suicide …

Stem cells have been extensively investigated as tumour-tropic vectors for gene delivery to
solid tumours. In this review, we discuss the potential for using stem cells as cellular vector …

Advances in gene-based medicine since 1990s have ushered in new therapeutic strategy of
gene therapy for inborn error genetic diseases and cancer. Malignant brain tumors such as …

Background Patients diagnosed with metastatic cancer have almost uniformly poor
prognoses. The treatments available for patients with disseminated disease are usually not …

Mesenchymal stem cells have a natural tropism for tumours and their metastases, and are
also considered immunoprivileged. This remarkable combination of properties has formed …

Gene therapy, which involves replacement of a defective gene with a functional, healthy
copy of that gene, is a potentially beneficial cancer treatment approach particularly over …

Systemic administration of currently manufactured viral stocks has not so far achieved
sufficient circulating titers to allow therapeutic targeting of metastatic disease. This is due to …

Gene therapy offers a multidimensional set of approaches intended to treat and cure
glioblastoma (GBM), in combination with the existing standard-of-care treatment (surgery …