Highlights•• TDP-43 pathology cannot be explained only by gene mutations.•• Domain-
specific protein interaction network begin to reveal the canonical pathways.•• Location of …

Introduction: TAR DNA-binding protein-43 (TDP-43) is a ubiquitously expressed RNA-
binding protein belonging to the hnRNP family of nuclear proteins. In human disease, its …

Transactive response DNA binding protein (TDP-43) is a key player in neurodegenerative
diseases. In this review, we have gathered and presented structural information on the …

TDP-43 is the primary or secondary pathological hallmark of neurodegenerative diseases,
such as amyotrophic lateral sclerosis, half of frontotemporal dementia cases, and limbic age …

TDP-43 is an RNA-binding protein that has been robustly linked to the pathogenesis of a
number of neurodegenerative disorders, including amyotrophic lateral sclerosis and …

Accumulation of TDP-43 in the cytoplasm of diseased neurons is the pathological hallmark
of frontotemporal dementia-TDP (FTLD-TDP) and amyotrophic lateral sclerosis (ALS), two …

Introduction: Nuclear factor TDP-43 is a ubiquitously expressed RNA binding protein that
plays a key causative role in several neurodegenerative diseases, especially in the …

TDP-43 nuclear protein is involved in several major neurodegenerative diseases that
include frontotemporal lobar degeneration with ubiquitin (FTLD-U) bodies and amyotrophic …

Our understanding of amyotrophic lateral sclerosis and frontotemporal dementia has
advanced dramatically since the discovery of cytoplasmic TAR DNA-binding protein 43 (TDP …

Transactive response DNA-binding protein 43 kDa (TDP-43) was identified as a major
disease-associated component in the brain of patients with amyotrophic lateral sclerosis …